The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

Malignant melanoma is one of the most aggressive forms of cancer and the leading cause of
death from skin tumors. Given the increased incidence of melanoma diagnoses in recent …

Lipid-based carriers represent the most widely used alternative to viral vectors for gene
expression and gene silencing purposes. This class of non-viral vectors is particularly …

Messenger RNA (mRNA) has recently emerged with remarkable potential as an effective
alternative to DNA-based therapies because of several unique advantages. mRNA does not …

Glioblastoma (GBM) is an aggressive central nervous system cancer with a dismal
prognosis. The standard of care involves surgical resection followed by radiotherapy and …

Nucleic acid-based bioactive substances have recently emerged as a new class of next-
generation therapeutics, but their development has been limited by their relatively weak …

Melanoma is a highly aggressive form of skin cancer with a very poor prognosis and
excessive resistance to current conventional treatments. Recently, the application of the …

Nucleic acid therapeutics (NATs) are valuable tools in the modulation of gene expression in
a highly specific manner. So far, NATs have been actively pursued in both pre-clinical and …

Self-amplifying RNA or RNA replicon is a form of nucleic acid-based vaccine derived from
either positive-strand or negative-strand RNA viruses. The gene sequences encoding …

Nonviral gene therapy using gemini surfactants is a unique approach to medicine that can
be adapted toward the treatment of various diseases. Recently, gemini surfactants have …