The drivers, mechanisms, and consequences of genome instability in HPV-driven cancers

VL Porter, MA Marra - Cancers, 2022 - mdpi.com
Simple Summary Cells infected with high-risk human papillomaviruses (HPV) can
accumulate DNA damage and eventually transform into HPV-driven cancers. Genome …

Human papillomavirus associated cervical lesion: pathogenesis and therapeutic interventions

J Ye, L Zheng, Y He, X Qi - MedComm, 2023 - Wiley Online Library
Human papillomavirus (HPV) is the most prevalent sexually transmitted virus globally.
Persistent high‐risk HPV infection can result in cervical precancerous lesions and cervical …

Direct comparison of HPV16 viral genomic integration, copy loss, and structural variants in oropharyngeal and uterine cervical cancers reveal distinct relationships to …

TP Schrank, S Kim, H Rehmani, A Kothari, D Wu… - Cancers, 2022 - mdpi.com
Simple Summary HPV16 causes approximately 60% of uterine cervical cancer and 95% of
HPV-driven oropharynx cancers. Despite both being HPV-associated, these tumors are very …

The role of HR-HPV integration in the progression of premalignant lesions into different cancer types.

O Catalán-Castorena, OL Garibay-Cerdenares… - Heliyon, 2024 - cell.com
High-risk human papillomavirus (HR-HPV) is associated with the development of different
types of cancer, such as cervical, head and neck (including oral, laryngeal, and …

Value of high‑risk human papillomavirus detection combined with colposcopy in the diagnosis of cervical cancer and precancerous lesions

P Wang, D Gao, X Yu, G Zhu - Oncology Letters, 2024 - spandidos-publications.com
In the present study, the diagnostic value of high risk‑human papillomavirus (HR‑HPV)
combined with colposcopy for the detection of cervical cancer and precancerous lesions …

The structure, activity, and function of the setd3 protein histidine methyltransferase

A Witecka, S Kwiatkowski, T Ishikawa, J Drozak - Life, 2021 - mdpi.com
SETD3 has been recently identified as a long sought, actin specific histidine
methyltransferase that catalyzes the Nτ-methylation reaction of histidine 73 (H73) residue in …

Malignancy and viral infections in Sub-Saharan Africa: A review

M Diakite, K Shaw-Saliba, CY Lau - Frontiers in Virology, 2023 - frontiersin.org
The burden of malignancy related to viral infection is increasing in Sub-Saharan Africa
(SSA). In 2018, approximately 2 million new cancer cases worldwide were attributable to …

[PDF][PDF] Insights into tumor microenvironment and HPV integrations in cervical cancer pathogenesis revealed by single-cell transcriptome data

F Peng, X Zeng, Z Wang, Y Sha, RKK Leung, KCC LAI… - 2024 - scholar.archive.org
Background HPV infection is prevalent among women, and can lead to severe diseases.
This study leverages singlecell RNA-sequencing (scRNA-seq), a cutting-edge technology …

Discovery of HPV-associated genomic alterations in cervical cancer

VL Porter - 2024 - open.library.ubc.ca
Human papillomavirus (HPV) is the necessary driver of cervical cancer, a disease that
largely affects females from underdeveloped nations and is prevalent among HIV-positive …

Generating human papillomavirus (HPV) reference databases to maximize genomic mapping

V Trevino, M Oyervides, GA Ramírez-Correa… - Archives of Virology, 2022 - Springer
Genomic experiments analyzing human papillomaviruses (HPVs) require a carefully
selected list of sequences as a reference database to map millions of reads. The available …