The ontogeny and maturation of the immune system is modulated by the microbiota. During
fetal life, the mother's microbiota produces compounds that are transferred to the fetus and …

Anticancer agents continue to dominate the list of newly approved drugs, approximately half
of which are immunotherapies. This trend illustrates the considerable promise of cancer …

Immune-checkpoint blockade (ICB) demonstrated inspiring effect and great promise in anti-
cancer therapy. However, many obstacles, such as drug resistance and difficulty in patient …

The primary function of myeloid cells is to protect the host from infections. However, during
cancer progression or states of chronic inflammation, these cells develop into myeloid …

In recent years, an increasing number of studies have reported that intestinal microbiota
have an important effect on tumour immunity by affecting the tumour microenvironment …

Pioneering studies from the early 1980s suggested that bacterial peptidoglycan-derived
muramyl peptides (MPs) could exert either stimulatory or immunosuppressive functions …

Dysregulated fatty acid metabolism interacts with oncogenic signals, thereby worsening
tumor aggressiveness. The stearoyl-CoA desaturating enzymes, SCD1 and SCD5, convert …

Gut microbiota and their metabolites are instrumental in regulating intestinal homeostasis.
However, early-life microbiota associated influences on intestinal development remain …

Microbes are widely present in various organs of the human body and play important roles
in numerous physiological and pathological processes. Nevertheless, owing to multiple …

Chronic stress is thought to be involved in the occurrence and progression of multiple
diseases, via mechanisms that still remain largely unknown. Interestingly, key regulators of …