New and emerging approaches to treat psychiatric disorders
Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …
the lives of millions of people worldwide. Although their etiological and diagnostic …
Effects of repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex on symptom domains in neuropsychiatric disorders: a systematic review …
Background The left dorsolateral prefrontal cortex is a prime target for repetitive transcranial
magnetic stimulation (TMS) to treat neuropsychiatric disorders; thus, abundant efficacy data …
magnetic stimulation (TMS) to treat neuropsychiatric disorders; thus, abundant efficacy data …
Biological factors influencing depression in later life: role of aging processes and treatment implications
SM Szymkowicz, AR Gerlach, D Homiack… - Translational …, 2023 - nature.com
Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …
Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale
The gabapentinoids, gabapentin, and pregabalin, target the α2δ subunits of voltage-gated
calcium channels. Initially licensed for pain and seizures, they have become widely …
calcium channels. Initially licensed for pain and seizures, they have become widely …
A cognitive biotype of depression and symptoms, behavior measures, neural circuits, and differential treatment outcomes: a Prespecified secondary analysis of a …
Importance Cognitive deficits in depression have been associated with poor functional
capacity, frontal neural circuit dysfunction, and worse response to conventional …
capacity, frontal neural circuit dysfunction, and worse response to conventional …
[HTML][HTML] One size does not fit all: methodological considerations for brain-based predictive modeling in psychiatry
Psychiatric illnesses are heterogeneous in nature. No illness manifests in the same way
across individuals, and no two patients with a shared diagnosis exhibit identical symptom …
across individuals, and no two patients with a shared diagnosis exhibit identical symptom …
Ketamine's acute effects on negative brain states are mediated through distinct altered states of consciousness in humans
Ketamine commonly and rapidly induces dissociative and other altered states of
consciousness (ASCs) in humans. However, the neural mechanisms that contribute to these …
consciousness (ASCs) in humans. However, the neural mechanisms that contribute to these …
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety
There is an urgent need to derive quantitative measures based on coherent neurobiological
dysfunctions or 'biotypes' to enable stratification of patients with depression and anxiety. We …
dysfunctions or 'biotypes' to enable stratification of patients with depression and anxiety. We …
Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity
AS Widge - Neuropsychopharmacology, 2024 - nature.com
Deep brain stimulation (DBS) is an invasive approach to precise modulation of
psychiatrically relevant circuits. Although it has impressive results in open-label psychiatric …
psychiatrically relevant circuits. Although it has impressive results in open-label psychiatric …