Browning of the white adipose tissue regulation: New insights into nutritional and metabolic relevance in health and diseases

SA Machado, G Pasquarelli-do-Nascimento… - Nutrition & …, 2022 - Springer
Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

Diagnosis, prevalence, and mortality of sarcopenia in dialysis patients: a systematic review and meta‐analysis

X Shu, T Lin, H Wang, Y Zhao, T Jiang… - Journal of cachexia …, 2022 - Wiley Online Library
There is no consensus on the prevalence of sarcopenia or its impact on mortality in end‐
stage renal disease patients undergoing dialysis. This review aimed to summarize the …

The interplay of immunology and cachexia in infection and cancer

H Baazim, L Antonio-Herrera… - Nature Reviews …, 2022 - nature.com
Diverse inflammatory diseases, infections and malignancies are associated with wasting
syndromes. In many of these conditions, the standards for diagnosis and treatment are …

Molecular mechanisms linking exercise to cancer prevention and treatment

P Hojman, J Gehl, JF Christensen, BK Pedersen - Cell metabolism, 2018 - cell.com
The benefits of exercise training for cancer patients are becoming increasingly evident.
Physical exercise has been shown to reduce cancer incidence and inhibit tumor growth …

Parathyroid hormone directs bone marrow mesenchymal cell fate

Y Fan, J Hanai, PT Le, R Bi, D Maridas, V DeMambro… - Cell metabolism, 2017 - cell.com
Intermittent PTH administration builds bone mass and prevents fractures, but its mechanism
of action is unclear. We genetically deleted the PTH/PTHrP receptor (PTH1R) in …

Understanding the molecular basis of anorexia and tissue wasting in cancer cachexia

E Yeom, K Yu - Experimental & Molecular Medicine, 2022 - nature.com
Cancer cachexia syndrome is a major cause of morbidity and mortality in cancer patients in
the advanced stage. It is a devastating disorder characterized by nutritional impairment …

Mechanisms of metabolic dysfunction in cancer-associated cachexia

M Petruzzelli, EF Wagner - Genes & development, 2016 - genesdev.cshlp.org
Metabolic dysfunction contributes to the clinical deterioration observed in advanced cancer
patients and is characterized by weight loss, skeletal muscle wasting, and atrophy of the …

Induction of adipose tissue browning as a strategy to combat obesity

A Kuryłowicz, M Puzianowska-Kuźnicka - International journal of …, 2020 - mdpi.com
The ongoing obesity pandemic generates a constant need to develop new therapeutic
strategies to restore the energy balance. Therefore, the concept of activating brown adipose …

Adipose tissue: between the extremes

A Vegiopoulos, M Rohm, S Herzig - The EMBO journal, 2017 - embopress.org
Adipose tissue represents a critical component in healthy energy homeostasis. It fulfills
important roles in whole‐body lipid handling, serves as the body's major energy storage …

Cancer-associated hypercalcemia

TA Guise, JJ Wysolmerski - New England Journal of Medicine, 2022 - Mass Medical Soc
Key Clinical Points Cancer-Associated Hypercalcemia Hypercalcemia complicates the
course of a variety of cancers when tumor factors overwhelm normal calcium and bone …