The human transglutaminase (TG) family consists of a structural protein, protein 4.2, that
lacks catalytic activity, and eight zymogens/enzymes, designated factor XIII-A (FXIII-A) and …

Metastasis of primary tumors to distant sites and their inherent or acquired resistance to
currently available therapies pose major clinical challenge to the successful treatment of …

Background Effective targeted therapy for sepsis requires an understanding of the
heterogeneity in the individual host response to infection. We investigated this heterogeneity …

Type I interferons are important in regulating immune responses to pathogens and tumors.
All interferons are considered to signal via the heterodimeric IFNAR1-IFNAR2 complex, yet …

Abstract Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that
catalyzes Ca (2+)-dependent protein modifications. In addition to being an enzyme, TG2 …

The CD38, possessing ADP-ribosyl cyclase (ADPR-cyclase) and cyclic ADP-ribose
hydrolase (cADPR-hydrolase), is able to regulate a variety of cellular activities. However, the …

Pulmonary fibrosis is a potentially life-threatening disease that may be caused by overt or
asymptomatic inflammatory responses. However, the precise mechanisms by which tissue …

The significant influence of tumor microenvironment on malignant cells has been
investigated with enthusiasm in this era of targeted therapy. Transglutaminase 2 (TG2, EC …

Transglutaminases are a family of eight currently known calcium-dependent enzymes that
catalyze the cross-linking or deamidation of proteins. They are involved in important …

Transglutaminase type II (TG2) is a pleiotropic enzyme that exhibits various activities
unrelated to its originally identified functions. Apart from post-translational modifications of …