Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer

L Kooshki, P Mahdavi, S Fakhri, EK Akkol, H Khan - Biofactors, 2022 - Wiley Online Library
Anticancer drugs are not purely effective because of their toxicity, side effects, high cost,
inaccessibility, and associated resistance. On the other hand, cancer is a complex public …

Therapeutic potential of jasmonic acid and its derivatives

I Jarocka-Karpowicz, A Markowska - International Journal of Molecular …, 2021 - mdpi.com
A modern method of therapeutic use of natural compounds that would protect the body are
jasmonates. The main representatives of jasmonate compounds include jasmonic acid and …

A novel microcrystalline BAY-876 formulation achieves long-acting antitumor activity against aerobic glycolysis and proliferation of hepatocellular carcinoma

H Yang, MZ Zhang, H Sun, Y Chai, X Li, Q Jiang… - Frontiers in …, 2021 - frontiersin.org
BAY-876 is an effective antagonist of the Glucose transporter type 1 (GLUT1) receptor, a
mediator of aerobic glycolysis, a biological process considered a hallmark of hepatocellular …

Orchestral role of lipid metabolic reprogramming in T-cell malignancy

A Mehta, YK Ratre, VK Soni, D Shukla… - Frontiers in …, 2023 - frontiersin.org
The immune function of normal T cells partially depends on the maneuvering of lipid
metabolism through various stages and subsets. Interestingly, T-cell malignancies also …

Glutor, a glucose transporter inhibitor, exerts antineoplastic action on tumor cells of thymic origin: Implication of modulated metabolism, survival, oxidative stress …

MK Temre, S Yadav, Y Goel, SK Pandey… - Frontiers in …, 2022 - frontiersin.org
Neoplastic cells overexpress glucose transporters (GLUT), particularly GLUT1 and GLUT3,
to support altered metabolism. Hence, novel strategies are being explored to effectively …

Natural products targeting glycolytic signaling pathways-an updated review on anti-cancer therapy

Y Cui, C Li, F Sang, W Cao, Z Qin… - Frontiers in …, 2022 - frontiersin.org
Glycolysis is a complex metabolic process that occurs to convert glucose into pyruvate to
produce energy for living cells. Normal cells oxidized pyruvate into adenosine triphosphate …

Reprogramming lipid metabolism as potential strategy for hematological malignancy therapy

L Zhang, N Chang, J Liu, Z Liu, Y Wu, L Sui… - Frontiers in …, 2022 - frontiersin.org
Hematological malignancies are one of the most lethal illnesses that seriously threaten
human life and health. Lipids are important constituents of various biological membranes …

[HTML][HTML] EZH2 activates Wnt/β-catenin signaling in human uterine fibroids, which is inhibited by the natural compound methyl jasmonate

M Ali, D Stone, A Laknaur, Q Yang, A Al-Hendy - F&S Science, 2023 - Elsevier
Objective To investigate the link between EZH2 and Wnt/β-catenin signaling and its role in
uterine fibroids (UFs) pathogenesis and explore the potential effect of natural compound …

Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of cancer-associated death in the West. This type of cancer has a very poor prognosis notably …

G Yang, Y Hori, A Couvineau - … mitochondrial dynamics and …, 2023 - books.google.com
Pancreatic cancers widely represented (> 90%) by pancreatic ductal adenocarcinoma
(PDAC) are the most lethal human digestive cancer with a very poor 5-year-survival rate …

[HTML][HTML] Diagnostic test of dynamic computed tomography in early gastrointestinal lymphoma and precancerous lesions

J Chen, Y Zhong, X Zeng, C Huang… - Translational Cancer …, 2022 - ncbi.nlm.nih.gov
Background In recent years, with the development of imaging technology, the accurate
diagnosis of precancerous lesions of digestive system and early lymphoma has attracted …