Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

Abstract The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …

Tuberous sclerosis complex (TSC) is a rare genetic disease causing multisystem growth of
benign tumours and other hamartomatous lesions, which leads to diverse and debilitating …

PTEN hamartoma tumor syndrome (PHTS) presents in a spectrum that encompasses the
eponymous disorders Cowden and Bannayan-Riley-Ruvalcaba. Herein, we delineate the …

Altering chromatin structure through histone posttranslational modifications has emerged as
a key driver of transcriptional responses in cells. Modulation of these transcriptional …

Mammalian target of rapamycin (mTOR) is a key protein kinase that regulates cell growth,
metabolism, and autophagy to maintain cellular homeostasis. Its activity is inhibited by …

PEComas are mesenchymal tumors composed of histologically and immunohistochemically
distinctive perivascular epithelioid cells that are characterized by the coexpression of muscle …

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by
epilepsy, intellectual disability, and benign tumors of the brain, heart, skin, and kidney …

Rationale: Lymphangioleiomyomatosis (LAM), occurring sporadically (S-LAM) or in patients
with tuberous sclerosis complex (TSC), results from abnormal proliferation of LAM cells …

Tuberous sclerosis complex (TSC) is a complex disease with many different clinical
manifestations. Despite the common opinion that TSC is a rare condition, with a mean …