Four-membered nitrogen-containing heterocycles are highly desirable functional groups
with synthetic and biological applications. Unsaturated four-membered N-heterocycles, 1 …

The syntheses of various heterocycles based on the ring expansion of azirines and azetines
are described. A structural diversity of heterocycles can be prepared starting from these …

A phosphine-catalyzed intermolecular asymmetric dearomatization reaction of
benzimidazoles with cyclopropenones has been developed. In the presence of 5 mol% of …

Brønsted acid catalyzed tandem cyclization was found to be highly effective for the
preparation of a series of polysubstituted 4-pyrones from diynones (yield up to 99%). 4 …

The first in-flow difluorocarbene generation and addition to alkenes and alkynes is reported.
The application of continuous flow technology allowed for the controlled generation of …

A facile, efficient and general synthetic method for iodopyridines is described. When treated
with molecular iodine in the presence of sodium bicarbonate, N-propargylic β-enaminones …

The reaction of cyclopropenones with pyridines, having an attached integer-charged
electron-withdrawing group (pyridinium, imidazolium, and phosphonium) was discovered to …

An efficient copper‐catalyzed tandem aerobic oxidative annulation and carbon‐carbon bond
cleavage reaction was developed from easily accessible arylacetamides, which provides a …

An unprecedented organocatalyzed [3+ 2] annulation of cyclopropenones and β-ketoesters
has been developed. This reaction provides a direct approach to highly substituted …

Azetidines are unusual heterocyclic motifs that comprise key components of biologically
active molecules and provide desirable structural properties for drug discovery. While a …