Hepatocellular carcinoma (HCC) is one of the most common malignancies, with a very poor
prognosis. Despite significant improvements in diagnosis and treatment in recent years, the …

Apoptosis is the predominant mechanism of liver cell death in autoimmune hepatitis, and
interventions that can modulate this activity are emerging. The aim of this review was to …

The study aims to clarify the relation between chemosensitivity and HtrA1 expression, and
the possible way HtrA1 works. Drug-resistant cell line HepG2/ADM was induced by …

Methotrexate (MTX) has been widely used for rheumatoid arthritis therapy for a long time.
MTX is also used as an anticancer drug for various tumors. However, many studies have …

The inhibitor of apoptosis protein (IAP) genes are frequently overexpressed in malignancies.
Second mitochondria-derived activator of caspase (SMAC) mimetics, which target IAPs …

Background: Evasion of apoptosis contributes to the pathogenesis of solid tumours including
non-small cell lung cancer (NSCLC). Malignant cells resist apoptosis through over …

Dysregulation of apoptosis has been shown to contribute to many diseases, including
cancer formation, development and resistance, as well as neurodegenerative and …

The Bmi1 gene has been reported to play important roles in cancer initiation and
progression. The aim of this study was to investigate the effects of RNA interference (RNAi) …

Aim: The aim of the present study was to further improve the therapeutic effects for human
hepatocellular carcinoma (HCC) and reduce the damage in normal cells using a novel …

Our previous studies and those of others have indicated that X-linked inhibitor of apoptosis
protein (XIAP) holds promise as a target gene in colon cancer gene therapy. In this study, we …