The role of fluorine in drug design and development is expanding rapidly as we learn more
about the unique properties associated with this unusual element and how to deploy it with …

In recent years, important changes have occurred in the field of diabetes treatment. The
focus of the treatment of diabetic patients has shifted from the control of blood glucose itself …

Emerging as an epidemic of the 21st century type 2 diabetes has become a major health
problem throughout the globe. The number of deaths attributable to diabetes reflects the …

Abstract Dipeptidyl peptidase-4 (DPP-4) is one of the widely explored novel targets for Type
2 diabetes mellitus (T2DM) currently. Research has been focused on the strategy to …

Piperazine scaffolds are a group of heterocyclic atoms having pharmacological values and
showing significant results in pharmaceutical chemistry. Piperazine has a flexible core …

Aim: To develop imeglimin-inspired novel 1, 3, 5-triazine derivatives as antidiabetic agents.
Materials & methods: These derivatives were synthesized and tested against DPP enzymes …

Abstract Dipeptidyl peptidase (DPP)-4 inhibitors are a class of orally available, small
molecule inhibitors that prolong the insulinotropic activity of the incretin hormone glucagon …

Diabetes mellitus (DM) remains a global health concern, causing significant mortality and
morbidity annually. Type-2 DM is the most prevalent and oral anti-diabetic drugs play a vital …

Starting from the lead isodaphnetin, a natural product inhibitor of DPP-4 discovered through
a target fishing docking based approach, a series of novel 2-phenyl-3, 4-dihydro-2 H-benzo …

Considerable effort has been made to achieve less frequent dosing in the development of
DPP-4 inhibitors. Enthusiasm for long-acting DPP-4 inhibitors is based on the promise that …