The sinus node is a collection of highly specialised cells constituting the heart's pacemaker.
The molecular underpinnings of its pacemaking abilities are debated. Using high-resolution …

Spontaneous beating of the sinoatrial node (SAN), the primary pacemaker of the heart, is
initiated, sustained, and regulated by a complex system that integrates ion channels and …

The sinoatrial node (SAN) is the primary pacemaker of the heart. Normal SAN function is
crucial in maintaining proper cardiac rhythm and contraction. Sinus node dysfunction (SND) …

Dysfunction of the sinoatrial node (SAN), the natural heart pacemaker, is common in heart
failure (HF) patients. SAN spontaneous activity relies on various ion currents in the plasma …

Background: Purkinje fibers (PFs) control timing of ventricular conduction and play a key role
in arrhythmogenesis in heart failure (HF) patients. We investigated the effects of HF on PFs …

Diabetic patients often have impaired heart rate (HR) control. HR is regulated both
intrinsically within the sinoatrial node (SAN) and via neuronal input. Previously, we found …

Background The vagus nerve plays an important role in neuroimmune interactions and in
the regulation of inflammation. A major source of efferent vagus nerve fibers that contribute …

Since its discovery, the sinoatrial node (SAN) has represented a fascinating and complex
matter of research. Despite over a century of discoveries, a full comprehension of …

In adult mammalian hearts, atrioventricular rings (AVRs) surround the atrial orifices of
atrioventricular valves and are hotbed of ectopic activity in patients with focal atrial …

Objective. The objective is to observe the synergistic and attenuating effect of
electroacupuncture (EA) on aconitine (ACO) in improving heart failure (HF) and to explore its …