HIV-1 accessory proteins—ensuring viral survival in a hostile environment
MH Malim, M Emerman - Cell host & microbe, 2008 - cell.com
One of the features of primate immunodeficiency viruses (HIVs and SIVs) that distinguishes
them from other retroviruses is the array of" accessory" proteins they encode. Here, we …
them from other retroviruses is the array of" accessory" proteins they encode. Here, we …
Modulation of HIV-1-host interaction: role of the Vpu accessory protein
Viral protein U (Vpu) is a type 1 membrane-associated accessory protein that is unique to
human immunodeficiency virus type 1 (HIV-1) and a subset of related simian …
human immunodeficiency virus type 1 (HIV-1) and a subset of related simian …
The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein
N Van Damme, D Goff, C Katsura, RL Jorgenson… - Cell host & …, 2008 - cell.com
The HIV-1 accessory protein Vpu counteracts a host factor that restricts virion release from
infected cells. Here we show that the interferon-induced cellular protein BST-2/HM1 …
infected cells. Here we show that the interferon-induced cellular protein BST-2/HM1 …
Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a βTrCP-dependent mechanism
JL Douglas, K Viswanathan, MN McCarroll… - Journal of …, 2009 - Am Soc Microbiol
The primary roles attributed to the human immunodeficiency virus type 1 (HIV-1) Vpu protein
are the degradation of the viral receptor CD4 and the enhancement of virion release. With …
are the degradation of the viral receptor CD4 and the enhancement of virion release. With …
Antagonism to and intracellular sequestration of human tetherin by the human immunodeficiency virus type 2 envelope glycoprotein
A Le Tortorec, SJD Neil - Journal of virology, 2009 - Am Soc Microbiol
ABSTRACT Tetherin (CD317/BST-2), an interferon-induced membrane protein, restricts the
release of nascent retroviral particles from infected cell surfaces. While human …
release of nascent retroviral particles from infected cell surfaces. While human …
HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membrane
SJD Neil, SW Eastman, N Jouvenet… - PLoS …, 2006 - journals.plos.org
The human immunodeficiency virus (HIV) type-1 viral protein U (Vpu) protein enhances the
release of diverse retroviruses from human, but not monkey, cells and is thought to do so by …
release of diverse retroviruses from human, but not monkey, cells and is thought to do so by …
Sequence of human immunodeficiency virus type 1 (HIV-1) Gag localization and oligomerization monitored with live confocal imaging of a replication-competent …
The assembly of infectious human immunodeficiency virus (HIV) requires that Gag transport
and oligomerization be coordinated with its association with other viral proteins, viral RNAs …
and oligomerization be coordinated with its association with other viral proteins, viral RNAs …
Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment
M Dubé, B Bhusan Roy, P Guiot-Guillain… - PLoS …, 2010 - journals.plos.org
The Vpu accessory protein promotes HIV-1 release by counteracting Tetherin/BST-2, an
interferon-regulated restriction factor, which retains virions at the cell-surface. Recent reports …
interferon-regulated restriction factor, which retains virions at the cell-surface. Recent reports …
HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor
C Goffinet, I Allespach, S Homann, HM Tervo… - Cell host & …, 2009 - cell.com
Mammals encode proteins that inhibit viral replication at the cellular level. In turn, certain
viruses have evolved genes that can functionally counteract these intrinsic restrictions …
viruses have evolved genes that can functionally counteract these intrinsic restrictions …
Human immunodeficiency virus type 1 assembly, budding, and cell-cell spread in T cells take place in tetraspanin-enriched plasma membrane domains
C Jolly, QJ Sattentau - Journal of virology, 2007 - Am Soc Microbiol
Human immunodeficiency virus type-1 (HIV-1) egress from infected CD4+ T cells is thought
to be via assembly and budding at the plasma membrane and may involve components of …
to be via assembly and budding at the plasma membrane and may involve components of …