Abstract Glutathione-S-transferases (GSTs) are a family of Phase II detoxification enzymes
that catalyse the conjugation of glutathione (GSH) to a wide variety of endogenous and …

Increased efforts in antimalarial drug discovery are urgently needed. The goal must be to
develop safe and affordable new drugs to counter the spread of malaria parasites that are …

The drug market is still dominated by small molecules, and more than 80% of the clinical
development of drug candidates in the top 20 pharmaceutical firms is still based on small …

Experimenta naturae, like the glucose-6-phosphate dehydrogenase deficiency, indicate that
malaria parasites are highly susceptible to alterations in the redox equilibrium. This offers a …

Malaria is a disease that affects nearly 40% of the global population, and chemotherapy
remains the mainstay of its control strategy. The global malaria situation is increasingly …

Approximately 40% of the world population live in areas with the risk of malaria. Each year,
300–500 million people suffer from acute malaria, and 0.5–2.5 million die from the disease …

Background Schistosomiasis—infection with helminth parasites in the genus Schistosoma,
including S. mansoni—is a widespread, devastating tropical disease affecting more than …

Late-stage modification of drug molecules is a fast method to introduce diversity into the
already biologically active scaffold. A notable number of analogs of mefloquine, chloroquine …

Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

Methylene blue has intrinsic antimalarial activity and it can act as a chloroquine sensitizer. In
addition, methylene blue must be considered for preventing methemoglobinemia, a serious …