The chemokine superfamily consists of a large number of ligands and receptors. At first
glance, this family appears redundant and their ligand-receptor relationships promiscuous …

The generation of a functional and diverse repertoire of T cells occurs in the thymus from
precursors arriving from the bone marrow. In this article, we introduce the various stages of …

The thymus represents an epithelial–mesenchymal tissue, anatomically structured into
discrete cortical and medullary regions that contain phenotypically and functionally distinct …

The chemokine receptor CCR7 and its ligands CCL19 and CCL21 control a diverse array of
migratory events in adaptive immune function. Most prominently, CCR7 promotes homing of …

The continuous migration of immune cells between lymphoid and nonlymphoid organs is a
key feature of the immune system, facilitating the distribution of effector cells within nearly all …

The thymus is an intricate primary lymphoid organ, wherein bone marrow–derived lymphoid
progenitor cells are induced to develop into functionally competent T cells that express a …

The thymus produces self-tolerant functionally competent T cells. This process involves the
import of multipotent haematopoietic progenitors that are then signalled to adopt the T cell …

Chemokines were recognized originally for their ability to dictate the migration and activation
of leukocytes. However, CXC chemokine ligand 12 (CXCL12, also known as stromal cell …

The evolutionary emergence of vertebrates was accompanied by major morphological and
functional innovations, including the development of an adaptive immune system. Vertebrate …

Therapeutic interventions used for cancer treatment provoke thymus damage and limit the
recovery of protective immunity. Here, we show that eosinophils are an essential part of an …