Recent advances in oligonucleotide therapeutics in oncology

H Xiong, RN Veedu, SD Diermeier - International Journal of Molecular …, 2021 - mdpi.com
Cancer is one of the leading causes of death worldwide. Conventional therapies, including
surgery, radiation, and chemotherapy have achieved increased survival rates for many types …

Mesoporous silica nanoparticles for pulmonary drug delivery

A Garcia-Fernandez, F Sancenon… - Advanced Drug Delivery …, 2021 - Elsevier
Over the last years, respiratory diseases represent a clinical concern, being included among
the leading causes of death in the world due to the lack of effective lung therapies, mainly …

A perspective on oligonucleotide therapy: Approaches to patient customization

S Thakur, A Sinhari, P Jain, HR Jadhav - Frontiers in Pharmacology, 2022 - frontiersin.org
It is estimated that the human genome encodes 15% of proteins that are considered to be
disease-modifying. Only 2% of these proteins possess a druggable site that the approved …

Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update

M Mehta, DS Dhanjal, KR Paudel, B Singh… - …, 2020 - Springer
Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are
amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases …

Probing the links: Long non-coding RNAs and NF-κB signalling in atherosclerosis

MS Hussain, O Afzal, G Gupta, ASA Altamimi… - … -Research and Practice, 2023 - Elsevier
Atherosclerosis is a chronic inflammatory disease that involves the accumulation of lipids
and immune cells in the arterial wall. NF-kB signaling is a key regulator of inflammation and …

Antiproliferative effects of boswellic acid-loaded chitosan nanoparticles on human lung cancer cell line A549

N Solanki, M Mehta, DK Chellappan… - Future medicinal …, 2020 - Future Science
Aim: In the present study boswellic acids-loaded chitosan nanoparticles were synthesized
using ionic gelation technique. The influence of independent variables were studied and …

Nanomedicine-based delivery strategies for nucleic acid gene inhibitors in inflammatory diseases

E Fattal, F Fay - Advanced drug delivery reviews, 2021 - Elsevier
Thanks to their abilities to modulate the expression of virtually any genes, RNA therapeutics
have attracted considerable research efforts. Among the strategies focusing on nucleic acid …

Application of nanotechnology in drug delivery systems for respiratory diseases

MX Luo, S Hua, QY Shang - Molecular Medicine …, 2021 - spandidos-publications.com
Respiratory disease is a common disease with a high incidence worldwide, which is a
serious threat to human health, and is considered a societal and economic burden. The …

Perspectives and advancements in the design of nanomaterials for targeted cancer theranostics

YY Tan, PK Yap, GLX Lim, M Mehta, Y Chan… - Chemico-biological …, 2020 - Elsevier
Cancer continues to be one of the most challenging diseases to be treated and is one of the
leading causes of deaths around the globe. Cancers account for 13% of all deaths each …

Pulmonary siRNA delivery for lung disease: review of recent progress and challenges

L Ding, S Tang, TA Wyatt, DL Knoell… - Journal of controlled …, 2021 - Elsevier
Lung diseases are a leading cause of mortality worldwide and there exists urgent need for
new therapies. Approval of the first siRNA treatments in humans has opened the door for …