Soil is the habitat of countless organisms and encompasses an enormous variety of dynamic
environmental conditions. While it is evident that a thorough understanding of how …

Live-cell microscopy is a powerful tool that can reveal cellular behavior as well as the
underlying molecular processes. A key advantage of microscopy is that by visualizing …

Detecting and segmenting object instances is a common task in biomedical applications.
Examples range from detecting lesions on functional magnetic resonance images, to the …

An integrated account of the molecular changes occurring during the process of cellular
aging is crucial towards understanding the underlying mechanisms. Here, using novel …

Saccharomyces cerevisiae has been an important model for studying the molecular
mechanisms of aging in eukaryotic cells. However, the laborious and low-throughput …

Nuclear transport is facilitated by the Nuclear Pore Complex (NPC) and is essential for life in
eukaryotes. The NPC is a long-lived and exceptionally large structure. We asked whether …

Recently, efforts have been made to characterize the hallmarks that accompany and
contribute to the phenomenon of aging, as most relevant for humans 1. Remarkably …

Microfluidics coupled to quantitative time-lapse fluorescence microscopy is transforming our
ability to control, measure and understand signaling dynamics in single living cells. Here we …

The stochasticity of gene expression is manifested in the fluctuations of messenger
ribonucleic acid and protein copy numbers within a cell lineage over time. While data of this …

Cellular aging plays an important role in many diseases, such as cancers, metabolic
syndromes, and neurodegenerative disorders. There has been steady progress in …