Cholesterol plays an indispensable role in regulating the properties of cell membranes in
mammalian cells. Recent advances suggest that cholesterol exerts many of its actions …

Mammalian cells acquire cholesterol from low-density lipoprotein (LDL) and from
endogenous biosynthesis. The roles of the Niemann-Pick type C1 protein in mediating the …

Infections by the Ebola and Marburg filoviruses cause a rapidly fatal haemorrhagic fever in
humans for which no approved antivirals are available. Filovirus entry is mediated by the …

Lysosomal lipid accumulation, defects in membrane trafficking and altered Ca2+
homoeostasis are common features in many lysosomal storage diseases. Mucolipin …

Ebola and Marburg filoviruses cause deadly outbreaks of haemorrhagic fever. Despite
considerable efforts, no essential cellular receptors for filovirus entry have been identified …

Niemann-Pick type C1 disease is an autosomal-recessive lysosomal storage disorder. Loss
of function of the npc1 gene leads to abnormal accumulation of free cholesterol and …

Nonstandard abbreviations used: endoplasmic reticulum (ER); endocytic recycling
compartment (ERC); sterol response element–binding protein (SREBP); SREBP cleavage …

Intracellular cholesterol transport is essential for the maintenance of cholesterol
homeostasis. Many aspects of cholesterol metabolism are well-known, including its …

The Niemann-Pick C1 (NPC1) protein is predicted to be a polytopic glycoprotein, and it
contains a region with extensive homology to the sterol-sensing domains (SSD) of 3-hydroxy …

Abstract The 'sterol-sensing domain'(SSD) is conserved across phyla and is present in
several membrane proteins, such as Patched (a Hedgehog receptor) and NPC-1 (the …