[HTML][HTML] Manganese acquisition and homeostasis at the host-pathogen interface

JP Lisher, DP Giedroc - Frontiers in cellular and infection microbiology, 2013 - frontiersin.org
Pathogenic bacteria acquire transition metals for cell viability and persistence of infection in
competition with host nutritional defenses. The human host employs a variety of …

Zinc homeostasis at the bacteria/host interface—from coordination chemistry to nutritional immunity

J Wątły, S Potocki… - Chemistry–A European …, 2016 - Wiley Online Library
Zinc is one of the most important metal nutrients for species from all kingdoms, being a key
structural or catalytic component of hundreds of enzymes, crucial for the survival of both …

[HTML][HTML] Mechanical characteristics, in vitro degradation, cytotoxicity, and antibacterial evaluation of Zn-4.0 Ag alloy as a biodegradable material

P Li, C Schille, E Schweizer, F Rupp, A Heiss… - International journal of …, 2018 - mdpi.com
Zn-based biodegradable metallic materials have been regarded as new potential
biomaterials for use as biodegradable implants, mainly because of the ideal degradation …

High-resolution analysis of the pneumococcal transcriptome under a wide range of infection-relevant conditions

R Aprianto, J Slager, S Holsappel… - Nucleic acids …, 2018 - academic.oup.com
Streptococcus pneumoniae is an opportunistic human pathogen that typically colonizes the
nasopharyngeal passage and causes lethal disease in other host niches, such as the lung …

[HTML][HTML] Advances in the molecular understanding of biological zinc transport

CA Blindauer - Chemical Communications, 2015 - pubs.rsc.org
Between 5 and 10% of all proteins of a given organism are estimated to require zinc for
function, and hence zinc is essential for almost any given metabolic process. It is therefore of …

Role of copper efflux in pneumococcal pathogenesis and resistance to macrophage-mediated immune clearance

MDL Johnson, TE Kehl-Fie, R Klein, J Kelly… - Infection and …, 2015 - Am Soc Microbiol
In bacteria, the intracellular levels of metals are mediated by tightly controlled acquisition
and efflux systems. This is particularly true of copper, a trace element that is universally toxic …

The Adc/Lmb system mediates zinc acquisition in Streptococcus agalactiae and contributes to bacterial growth and survival

P Moulin, K Patron, C Cano, MA Zorgani… - Journal of …, 2016 - Am Soc Microbiol
ABSTRACT The Lmb protein of Streptococcus agalactiae is described as an adhesin that
binds laminin, a component of the human extracellular matrix. In this study, we revealed a …

[HTML][HTML] The roles of transition metals in the physiology and pathogenesis of Streptococcus pneumoniae

ES Honsa, MDL Johnson, JW Rosch - Frontiers in cellular and …, 2013 - frontiersin.org
For bacterial pathogens whose sole environmental reservoir is the human host, the
acquisition of essential nutrients, particularly transition metals, is a critical aspect of survival …

[HTML][HTML] Transcriptional and metabolic effects of glucose on Streptococcus pneumoniae sugar metabolism

L Paixao, J Caldas, TG Kloosterman… - Frontiers in …, 2015 - frontiersin.org
Streptococcus pneumoniae is a strictly fermentative human pathogen that relies on
carbohydrate metabolism to generate energy for growth. The nasopharynx colonized by the …

[HTML][HTML] Two zinc-binding domains in the transporter AdcA from Streptococcus pyogenes facilitate high-affinity binding and fast transport of zinc

K Cao, N Li, H Wang, X Cao, J He, B Zhang… - Journal of Biological …, 2018 - ASBMB
Zinc is an essential metal in bacteria. One important bacterial zinc transporter is AdcA, and
most bacteria possess AdcA homologs that are single-domain small proteins due to better …