Current therapeutic targets in cancer cachexia: a pathophysiologic approach

KC Kadakia, JM Hamilton-Reeves… - American Society of …, 2023 - ascopubs.org
Significant progress in our understanding of cancer cachexia has occurred in recent years.
Despite these advances, no pharmacologic agent has achieved US Food and Drug …

Sarcopenia as a risk factor of progression-free survival in patients with metastases: a systematic review and meta-analysis

L Luo, X Shen, S Fang, T Wan, P Liu, P Li, H Tan, Y Fu… - BMC cancer, 2023 - Springer
Background Metastasis of cancer causes more than 90% of cancer deaths and is severely
damaging to human health. In recent years, several studies have linked sarcopenia to …

Adverse effects of systemic cancer therapy on skeletal muscle: myotoxicity comes out of the closet

P Klassen, DL Schiessel… - Current Opinion in Clinical …, 2023 - journals.lww.com
The adverse side effect of cancer therapy on skeletal muscle has been largely ignored in the
development of cancer therapeutics. Given the extent to which loss of muscle mass and …

Call for standardization in assessment and reporting of muscle and adipose change using computed tomography analysis in oncology: A scoping review

PN Klassen, VC Mazurak, J Thorlakson… - Journal of Cachexia …, 2023 - Wiley Online Library
Investigators are increasingly measuring skeletal muscle (SM) and adipose tissue (AT)
change during cancer treatment to understand impact on patient outcomes. Recent meta …

Prevalence and prognostic value of baseline sarcopenia in hematologic malignancies: a systematic review

X Zeng, L Zhang, Y Zhang, S Jia, T Lin, X Zhao… - Frontiers in …, 2023 - frontiersin.org
Background The correlation between sarcopenia and hematological malignancy prognosis
is still controversial. Design: A systematic review and meta-analysis. Objectives: To explore …

[HTML][HTML] Feasibility of two levels of protein intake in patients with colorectal cancer: findings from the Protein Recommendation to Increase Muscle (PRIMe) randomized …

KL Ford, MB Sawyer, S Ghosh, CF Trottier, IR Disi… - ESMO open, 2024 - Elsevier
Background Low muscle mass (MM) predicts unfavorable outcomes in cancer. Protein
intake supports muscle health, but oncologic recommendations are not well characterized …

Associations between outcome variables of nutritional screening methods and systemic treatment tolerance in patients with colorectal cancer: A systematic review

K Beukers, MJJ Voorn, R Trepels, J Vogelaar… - Journal of geriatric …, 2022 - Elsevier
Introduction Multiple screening methods for malnutrition are available, but a systematic
review of evidence in patients with colorectal cancer (CRC) is lacking. The aim of this study …

[HTML][HTML] Prevalence and clinical outcomes of sarcopenia in patients with esophageal, gastric or colorectal cancers receiving preoperative neoadjuvant therapy: A meta …

L Luo, Y Fan, Y Wang, Z Wang, J Zhou - Asia-Pacific Journal of Oncology …, 2024 - Elsevier
Objective To investigate the prevalence of sarcopenia and its impact on clinical outcomes in
patients with EC, GC, or CRC receiving neoadjuvant therapy through Meta-analysis …

Prognostic role of low-skeletal muscle mass on staging computed tomography in metastasized colorectal cancer: a systematic review and meta-analysis

HJ Meyer, A Strobel, A Wienke, A Surov - Clinical Colorectal Cancer, 2022 - Elsevier
Background Low-skeletal muscle mass (LSMM) is defined as skeletal muscle loss, which
can be assessed by imaging. Our aim was to establish the effect of LSMM on overall survival …

[HTML][HTML] Association between postoperative muscle wasting and survival in older patients undergoing surgery for non-metastatic colorectal cancer

TE Argillander, D Spek… - Journal of Geriatric …, 2021 - Elsevier
Background Preoperative sarcopenia in older patients is a risk factor for adverse outcomes
after colorectal cancer (CRC) surgery. Longitudinal changes in muscle mass in this group …