Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments

SN Lone, S Nisar, T Masoodi, M Singh, A Rizwan… - Molecular cancer, 2022 - Springer
Over the past decade, invasive techniques for diagnosing and monitoring cancers are slowly
being replaced by non-invasive methods such as liquid biopsy. Liquid biopsies have …

Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes

S Gurunathan, MH Kang, M Jeyaraj, M Qasim, JH Kim - Cells, 2019 - mdpi.com
Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids,
RNA, and DNA. They are derived from endocytic membranes and can transfer signals to …

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

B Costa-Silva, NM Aiello, AJ Ocean, S Singh… - Nature cell …, 2015 - nature.com
Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis,
mainly due to delayed detection. We hypothesized that intercellular communication is critical …

Exosomes: from garbage bins to promising therapeutic targets

M H. Rashed, E Bayraktar, G K. Helal… - International journal of …, 2017 - mdpi.com
Intercellular communication via cell-released vesicles is a very important process for both
normal and tumor cells. Cell communication may involve exosomes, small vesicles of …

Saliva diagnostics–Current views and directions

KE Kaczor-Urbanowicz… - Experimental …, 2017 - journals.sagepub.com
In this review, we provide an update on the current and future applications of saliva for
diagnostic purposes. There are many advantages of using saliva as a biofluid. Its collection …

Exosomes in cancer: small particle, big player

X Zhang, X Yuan, H Shi, L Wu, H Qian, W Xu - Journal of hematology & …, 2015 - Springer
Exosomes have emerged as a novel mode of intercellular communication. Exosomes can
shuttle bioactive molecules including proteins, DNA, mRNA, as well as non-coding RNAs …

Exosome mediated communication within the tumor microenvironment

L Milane, A Singh, G Mattheolabakis, M Suresh… - Journal of Controlled …, 2015 - Elsevier
It is clear that exosomes (endosome derived vesicles) serve important roles in cellular
communication both locally and distally and that the exosomal process is abnormal in …

Extracellular vesicles as biomarkers and therapeutic tools: from pre-clinical to clinical applications

MC Ciferri, R Quarto, R Tasso - Biology, 2021 - mdpi.com
Simple Summary Extracellular vesicles (EVs) are membrane-bound vesicles released by all
cell types, differing in biogenesis, physical characteristics, and contents. Due to their central …

Saliva diagnostics

T Nonaka, DTW Wong - Annual Review of Analytical Chemistry, 2022 - annualreviews.org
Cancer remains one of the leading causes of death, and early detection of this disease is
crucial for increasing survival rates. Although cancer can be diagnosed following tissue …

Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic …

C Kahlert, SA Melo, A Protopopov, J Tang… - Journal of Biological …, 2014 - ASBMB
Exosomes are small vesicles (50–150 nm) of endocytic origin that are released by many
different cell types. Exosomes in the tumor microenvironment may play a key role in …