Energy metabolism and maternal-fetal tolerance working in decidualization

X Meng, C Chen, J Qian, L Cui, S Wang - Frontiers in Immunology, 2023 - frontiersin.org
One pivotal aspect of early pregnancy is decidualization. The decidualization process
includes two components: the differentiation of endometrial stromal cells to decidual stromal …

Tryptophan metabolism and immune regulation in the human placenta

A Silvano, V Seravalli, N Strambi, M Cecchi… - Journal of Reproductive …, 2021 - Elsevier
The placenta represents the maternal-fetal vascular interface. It is capable of supplying the
bioenergetic needs of the developing conceptus. It is composed of different cell types that …

Cutting edge: the regulatory mechanisms of macrophage polarization and function during pregnancy

LL Wang, ZH Li, H Wang, J Kwak-Kim… - Journal of reproductive …, 2022 - Elsevier
Macrophages are highly diverse cells and represent the major antigen-presenting cell at the
maternal-fetal interface. Except for protecting the embryo with half of the paternal antigens …

The metabolic characteristic of decidual immune cells and their unique properties in pregnancy loss

T Zhang, HH Shen, XY Qin, MQ Li - Immunological reviews, 2022 - Wiley Online Library
Maternal tolerance to semi‐or fully allograft conceptus is a prerequisite for the maintenance
of pregnancy. Once this homeostasis is disrupted, it may result in pregnancy loss. As a …

Progesterone Activates the Histone Lactylation–Hif1α-glycolysis Feedback Loop to Promote Decidualization

W Zhao, Y Wang, J Liu, Q Yang, S Zhang, X Hu… - …, 2024 - academic.oup.com
Decidualization is a progesterone-dependent cellular differentiation process that is essential
for establishing pregnancy. Robust activation of glycolysis and lactate synthesis during …

Single-cell RNA-seq reveals developmental deficiencies in both the placentation and the decidualization in women with late-onset preeclampsia

J Yang, L Gong, Q Liu, H Zhao, Z Wang, X Li… - Frontiers in …, 2023 - frontiersin.org
Preeclampsia (PE) is a leading cause of maternal and fetal morbidity and mortality. Although
increasing lines of evidence suggest that both the placenta and the decidua likely play roles …

ATOH8 Expression Is Regulated by BMP2 and Plays a Key Role in Human Endometrial Stromal Cell Decidualization

R Thapa, L Druessel, L Ma, DS Torry, BM Bany - Endocrinology, 2024 - academic.oup.com
During the secretory phase of the menstrual cycle, elongated fibroblast-like mesenchymal
cells in the uterine endometrium begin to transdifferentiate into polygonal epithelioid-like …

Human chorionic gonadotropin-stimulated interleukin-4-induced-1 (IL4I1) promotes human decidualization via Aryl hydrocarbon receptor

JM Luo, TT Zhang, YY He, HN Luo, YQ Hong… - International Journal of …, 2023 - mdpi.com
Decidualization is necessary for the successful establishment of early pregnancy in rodents
and humans. Disturbed decidualization results in recurrent implantation failure, recurrent …

When the clock ticks wrong with COVID‐19

S Papagerakis, R Said, F Ketabat… - Clinical and …, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a member of the
coronavirus family that causes the novel coronavirus disease first diagnosed in 2019 …

The Long Non-Coding RNA Gene AC027288.3 Plays a Role in Human Endometrial Stromal Fibroblast Decidualization

R Thapa, K Marmo, L Ma, DS Torry, BM Bany - Cells, 2024 - mdpi.com
During the secretory phase of the menstrual cycle, endometrial fibroblast cells begin to
change into large epithelial-like cells called decidual cells in a process called …