Mechanisms of joint destruction in rheumatoid arthritis—immune cell–fibroblast–bone interactions

N Komatsu, H Takayanagi - Nature Reviews Rheumatology, 2022 - nature.com
Rheumatoid arthritis (RA) is characterized by inflammation and destruction of bone and
cartilage in affected joints. Autoimmune responses lead to increased osteoclastic bone …

Host and bacterial factors linking periodontitis and rheumatoid arthritis

A Krutyhołowa, K Strzelec, A Dziedzic… - Frontiers in …, 2022 - frontiersin.org
Observations from numerous clinical, epidemiological and serological studies link
periodontitis with severity and progression of rheumatoid arthritis. The strong association is …

YAP/TAZ: key players for rheumatoid arthritis severity by driving fibroblast like synoviocytes phenotype and fibro-inflammatory response

R Caire, E Audoux, G Courbon, E Michaud… - Frontiers in …, 2021 - frontiersin.org
Objective The role of YAP/TAZ, two transcriptional co-activators involved in several cancers,
was investigated in rheumatoid arthritis (RA). Methods Fibroblast like synoviocytes (FLS) …

Infectious triggers in periodontitis and the gut in rheumatoid arthritis (RA): A complex story about association and causality

B Möller, F Kollert, A Sculean, PM Villiger - Frontiers in immunology, 2020 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic immune mediated inflammatory disease of unknown
origin, which is predominantly affecting the joints. Antibodies against citrullinated peptides …

Porphyromonas gingivalis experimentally induces periodontis and an anti-CCP2-associated arthritis in the rat

G Courbon, M Rinaudo-Gaujous… - Annals of the …, 2019 - ard.bmj.com
Objectives Association between periodontal disease (PD) and rheumatoid arthritis (RA) has
been extensively described, but direct evidence of causal involvement of PD in RA is …

[PDF][PDF] RETRACTED: Silencing of Long Non-coding RNA HOTTIP Reduces Inflammation in Rheumatoid Arthritis by Demethylation of SFRP1

X Hu, J Tang, X Hu, P Bao, W Deng, J Wu… - … Therapy-Nucleic Acids, 2020 - cell.com
Accumulating evidence suggests long non-coding RNAs (lncRNAs) play crucial roles in the
pathogenesis of rheumatoid arthritis (RA). Here, we aimed to define the role of HOXA …

Antibodies to citrullinated proteins (ACPA) associate with markers of osteoclast activation and bone destruction in the bone marrow of patients with rheumatoid arthritis

W Kurowska, I Slowinska, Z Krogulec… - Journal of Clinical …, 2021 - mdpi.com
Normalizing bone metabolism is a challenge in rheumatoid arthritis (RA). Studies in mice
suggest that anti-citrullinated protein antibodies (ACPAs) can trigger osteoclast activation …

Bone Involvement in Rheumatoid Arthritis and Spondyloartritis: An Updated Review

F Orsini, C Crotti, G Cincinelli, R Di Taranto, A Amati… - Biology, 2023 - mdpi.com
Simple Summary Chronic inflammatory arthritis, such as rheumatoid arthritis (RA) and
spondyloarthritis (SpA), often have a significant impact on bone tissue, where bone is not …

Network pharmacology based research on the combination mechanism between escin and low dose glucocorticoids in anti-rheumatoid arthritis

L Zhang, Y Huang, C Wu, Y Du, P Li, M Wang… - Frontiers in …, 2019 - frontiersin.org
Rheumatoid arthritis (RA) is characterized by chronic progressive symmetrical synovitis and
destruction of multiple joints. Glucocorticoids (GCs) are widely used in the treatment of RA …

Positive and negative regulators of sclerostin expression

R Iwamoto, M Koide, N Udagawa… - International Journal of …, 2022 - mdpi.com
Sclerostin is secreted from osteocytes, binds to the Wnt co-receptor Lrp5/6, and affects the
interaction between Wnt ligands and Lrp5/6, which inhibits Wnt/β-catenin signals and …