Theory and simulation of multiphase coexistence in biomolecular mixtures
WM Jacobs - Journal of Chemical Theory and Computation, 2023 - ACS Publications
Biomolecular condensates constitute a newly recognized form of spatial organization in
living cells. Although many condensates are believed to form as a result of phase …
living cells. Although many condensates are believed to form as a result of phase …
Fundamental Aspects of Phase-Separated Biomolecular Condensates
Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …
understanding in much of molecular, cell, and developmental biology. There is an urgent …
Sequence-dependent material properties of biomolecular condensates and their relation to dilute phase conformations
D Sundaravadivelu Devarajan, J Wang… - Nature …, 2024 - nature.com
Material properties of phase-separated biomolecular condensates, enriched with disordered
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
The disordered N-terminal tail of SARS-CoV-2 Nucleocapsid protein forms a dynamic complex with RNA
Abstract The SARS-CoV-2 Nucleocapsid (N) protein is responsible for condensation of the
viral genome. Characterizing the mechanisms controlling nucleic acid binding is a key step …
viral genome. Characterizing the mechanisms controlling nucleic acid binding is a key step …
Quantitative reconstitution of yeast RNA processing bodies
SL Currie, W Xing, D Muhlrad… - Proceedings of the …, 2023 - National Acad Sciences
Many biomolecular condensates appear to form through liquid–liquid phase separation
(LLPS). Individual condensate components can often undergo LLPS in vitro, capturing some …
(LLPS). Individual condensate components can often undergo LLPS in vitro, capturing some …
Theoretical and data-driven approaches for biomolecular condensates
Biomolecular condensation processes are increasingly recognized as a fundamental
mechanism that living cells use to organize biomolecules in time and space. These …
mechanism that living cells use to organize biomolecules in time and space. These …
[HTML][HTML] Sequence-dependent material properties of biomolecular condensates and their relation to dilute phase conformations
DS Devarajan, J Wang, B Szała-Mendyk… - Nature …, 2024 - ncbi.nlm.nih.gov
Material properties of phase-separated biomolecular condensates, enriched with disordered
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
Enhancing Zinc Uptake through Dual‐Modification of Cicer arietinum Protein
Zinc is crucial for physiological processes; however, deficiency persists globally. Binding
zinc to plant proteins enhances absorption, minimizing toxicity risks and offering a potential …
zinc to plant proteins enhances absorption, minimizing toxicity risks and offering a potential …
Time-dependent material properties of aging biomolecular condensates from different viscoelasticity measurements in molecular dynamics simulations
AR Tejedor, R Collepardo-Guevara… - The Journal of …, 2023 - ACS Publications
Biomolecular condensates are important contributors to the internal organization of the cell
material. While initially described as liquid-like droplets, the term biomolecular condensates …
material. While initially described as liquid-like droplets, the term biomolecular condensates …
Challenges in studying the liquid-to-solid phase transitions of proteins using computer simulations
Abstract “Membraneless organelles,” also referred to as biomolecular condensates, perform
a variety of cellular functions and their dysregulation is implicated in cancer and …
a variety of cellular functions and their dysregulation is implicated in cancer and …