Single-cell multi-omics technologies and methods characterize cell states and activities by
simultaneously integrating various single-modality omics methods that profile the …

Single‐cell RNA sequencing (scRNA‐seq) technology has become the state‐of‐the‐art
approach for unravelling the heterogeneity and complexity of RNA transcripts within …

Bulk sequencing methodologies have allowed us to make great progress in cancer
research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic …

In the past decade, assays that profile different aspects of the epigenome have grown
exponentially in number and variation. However, standard guidelines for researchers to …

Amongst the most important outputs of the biopharmaceutical industry are recombinant
proteins, many of which are produced by integrating transgenes into the genomes of …

Cancer initiation is driven by the cooperation between genetic and epigenetic aberrations
that disrupt gene regulatory programs critical to maintaining specialized cellular functions …

Since Robert Hooke first described the existence of 'cells' in 1665, scientists have sought to
identify and further characterise these fundamental units of life. While our understanding of …

The liver is an immune organ that plays a vital role in the detection, capture, and clearance
of pathogens and foreign antigens that invade the human body. During acute and chronic …

Tumor tissues are constituted by a dynamic diversity of malignant and non-malignant cells,
which shape a puzzling biological ecosystem affecting cancer biology and response to …

In recent years, the emergence and development of single-cell sequencing technologies
have provided unprecedented opportunities to analyze deoxyribonucleic acid, ribonucleic …