Central nervous system (CNS) disorders affect as many as 1.5 billion people globally. The
limited delivery of most imaging and therapeutic agents into the brain is a major challenge …

Malignant brain tumors, a heterogeneous group of primary and metastatic neoplasms in the
central nervous system (CNS), are notorious for their highly invasive and devastating …

Besides the broad development of nanotechnological approaches for cancer diagnosis and
therapy, currently, there is no significant progress in the treatment of different types of brain …

Developing strategies toward safe and effective drug delivery into the central nervous
system (CNS) with improved targeting abilities and reduced off-target effects is crucial. CNS …

The blood–brain barrier (BBB) plays a vital role in the protection and maintenance of
homeostasis in the brain. In this way, it is an interesting target as an interface for various …

Central nervous system diseases are a heavy burden on society and health care systems.
Hence, the delivery of drugs to the brain has gained more and more interest. The brain is …

Alzheimer's disease (AD), the most common form of dementia, is a progressive and
multifactorial neurodegenerative disorder whose primary causes are mostly unknown. Due …

Glioblastoma (GBM) as the most common primary malignant brain tumor exhibits a high
incidence and degree of malignancy as well as poor prognosis. Due to the existence of …

Effective tumor treatment depends on optimizing drug penetration and accumulation in
tumor tissue while minimizing systemic toxicity. Nanomedicine has emerged as a key …

Glioblastoma multiforme (GBM) is the most common and lethal type of brain tumor, and the
clinically available approaches for its treatment are not curative. Despite the intensive …