The NOP receptor (nociceptin/orphanin FQ opioid peptide receptor) is the most recently
discovered member of the opioid receptor family and, together with its endogenous ligand …

Achieving effective pain management is one of the major challenges associated with
modern day medicine. Opioids, such as morphine, have been the reference treatment for …

Successful integration of advanced semiconductor devices with biological systems will
accelerate basic scientific discoveries and their translation into clinical technologies. In …

Chronic pain and posttraumatic stress disorder (PTSD) are disabling conditions that affect
biological, psychological, and social domains of functioning. Clinical research demonstrates …

Optogenetics has provided a revolutionary approach to dissecting biological phenomena.
However, the generation and use of optically active GPCRs in these contexts is limited and it …

Abstract Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide
with key regulatory functions in several central behavioral processes including motivation …

Despite high sequence similarity between NOP (nociceptin/orphanin FQ opioid peptide) and
opioid receptors, marked differences in endogenous ligand selectivity, signal transduction …

This paper is the thirty-fifth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2012 …

Post-translational modifications (PTMs) are key events in signal transduction since they
affect protein function by regulating their abundance and/or activity. PTMs involve the …

Following the identification of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) as an
endogenous ligand for the NOP receptor, ample evidence has revealed unique functional …