Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

Viruses are the cause of approximately 15% of all human cancers. Both RNA and DNA
human tumor viruses have been identified, with Merkel cell polyomavirus being the most …

Evasion of antitumour immunity is a hallmark of cancer. STING, a putative innate immune
signalling adaptor, has a pivotal role in mounting antitumour immunity by coordinating …

As a breakthrough strategy for cancer treatment, immunotherapy mainly consists of immune
checkpoint inhibitors (ICIs) and other immunomodulatory drugs that provide a durable …

DNA damage occurs throughout tumorigenesis and development. The immunogenicity of
DNA makes it an immune stimulatory molecule that initiates strong inflammatory responses …

Activating interferon responses with STING agonists (STINGa) is a current cancer
immunotherapy strategy, and therapeutic modalities that enable tumor-targeted delivery via …

Abstract STING (Stimulator of Interferon Genes) agonists have emerged as promising agents
in the field of cancer immunotherapy, owing to their excellent capacity to activate the innate …

Cancer immunotherapy with immune checkpoint inhibitors has achieved unprecedented
success in cancer treatment; However, only a subset of patients achieved clinical benefit …

The COVID-19 pandemic poses a serious global health threat. The rapid global spread of
SARS-CoV-2 highlights an urgent need to develop effective therapeutics for blocking SARS …

Cancer and its metastasis/recurrence still threaten human health, despite various advanced
treatments being employed. It is of great significance to develop simple drug formulations to …