Abstract Introduction. The alpha-2 adrenergic (AA-2) receptor agonists and imidazolines are
common exposures in the American Association of Poison Control Centers (AAPCC) …

Context: Following clonidine ingestion, naloxone is seldom administered as it is considered
ineffective in reversing somnolence, bradycardia, or hypotension. However, this conclusion …

Xylazine is a type of sedative commonly used in veterinary medicine. It acts on the central
alpha-2 receptor and suppresses norepinephrine release from the peripheral nerve …

Cardiac contractility requires the rhythmic generation of a myocardial action potential
conducted through the heart to coordinate myocardial contractions. Molecular studies have …

When considering toxic chemicals in the environment, a mechanistic, causal explanation of
toxicity may be preferred over a statistical or machine learning-based prediction by itself …

Background and objectives Clonidine has been clinically used to treat Tourette's syndrome
for decades. There was research finding that clonidine possessed the best risk-benefit ratio …

Exposure of neonatal animals to anesthetics may cause developmental functional changes
and acute structural anomalies in the brain. Clonidine, an α2-adrenoceptor agonist …

A 22-month-old girl without any significant medical history accidentally consumed a small
amount of a therapeutic compounding cream that contained camphor, gabapentin …

An 18-month-old child was brought to the emergency department (ED) by his mother for
evaluation of diarrhea, vomiting, and somnolence. He was lethargic, with “pinpoint” pupils …

Background Tizanidine, an α-2 adrenoceptor agonist, is widely prescribed for the
management of spasticity in adults. Case reports on pediatric tizanidine overdose are …