Intrinsically disordered proteins play diverse roles in cell signaling
Signaling pathways allow cells to detect and respond to a wide variety of chemical (eg Ca2+
or chemokine proteins) and physical stimuli (eg, sheer stress, light). Together, these …
or chemokine proteins) and physical stimuli (eg, sheer stress, light). Together, these …
Prolactin and vasoinhibin are endogenous players in diabetic retinopathy revisited
J Triebel, T Bertsch, C Clapp - Frontiers in Endocrinology, 2022 - frontiersin.org
Diabetic retinopathy (DR) and diabetic macular edema (DME) are major causes for visual
loss in adults. Nearly half of the world's population with diabetes has some degree of DR …
loss in adults. Nearly half of the world's population with diabetes has some degree of DR …
[HTML][HTML] Plasmin generates vasoinhibin-like peptides by cleaving prolactin and placental lactogen
C Friedrich, L Neugebauer, M Zamora… - Molecular and Cellular …, 2021 - Elsevier
Vasoinhibin is an antiangiogenic, profibrinolytic peptide generated by the proteolytic
cleavage of the pituitary hormone prolactin by cathepsin D, matrix metalloproteinases, and …
cleavage of the pituitary hormone prolactin by cathepsin D, matrix metalloproteinases, and …
New horizons in specific hormone proteolysis
Proteolysis of protein hormones is primarily acknowledged in the context of breakdown and
metabolic clearance by hepatorenal elimination. However, less explored is the specific …
metabolic clearance by hepatorenal elimination. However, less explored is the specific …
[HTML][HTML] A comparative phylogenetic analysis of prolactin cleavage sites for the generation of vasoinhibin in vertebrates
A Leuchs, N Davies, C Friedrich, S Trier… - General and …, 2022 - Elsevier
Vasoinhibin is a pleiotropic protein hormone with endocrine, autocrine, and paracrine effects
on blood vessel growth, permeability, and dilation, and a role in several human diseases. It …
on blood vessel growth, permeability, and dilation, and a role in several human diseases. It …