Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

Small ubiquitin-like modifiers (SUMOs) are essential for the regulation of several cellular
processes and are potential therapeutic targets owing to their involvement in diseases such …

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors elicit antitumour activity in
homologous recombination-defective cancers by trapping PARP1 in a chromatin-bound …

Small ubiquitin-like modifiers (SUMOs) are post-translational modifications (PTMs) that
regulate nuclear cellular processes. Here we used an augmented K0–SUMO proteomics …

The posttranslational modification of proteins by arginine methylation is functionally
important, yet the breadth of this modification is not well characterized. Using high-resolution …

Protein conjugation with Small ubiquitin-like modifier (SUMOylation) has critical roles during
cell cycle progression. Many important cell cycle regulators, including many oncogenes and …

SUMOylation, as a post-translational modification, plays essential roles in various biological
functions including cell growth, migration, cellular responses to stress and tumorigenesis …

Small ubiquitin-like modifiers (SUMOs) are post-translational modifications that play crucial
roles in most cellular processes. While methods exist to study exogenous SUMOylation …

Protein folding is a biophysical process by which proteins reach a specific three-dimensional
structure. The amino acid sequence of a polypeptide chain contains all the information …

Exposure of cells to heat or oxidative stress causes misfolding of proteins. To avoid toxic
protein aggregation, cells have evolved nuclear and cytosolic protein quality control (PQC) …