Synergistic hypolipidemic effects and mechanisms of phytochemicals: a review

Y Liu, C Liu, X Kou, Y Wang, Y Yu, N Zhen, J Jiang… - Foods, 2022 - mdpi.com
Hyperlipidemia, a chronic disorder of abnormal lipid metabolism, can induce obesity,
diabetes, and cardiovascular and cerebrovascular diseases such as coronary heart disease …

Drug Discovery against Acanthamoeba Infections: Present Knowledge and Unmet Needs

HM Elsheikha, R Siddiqui, NA Khan - Pathogens, 2020 - mdpi.com
Although major strides have been made in developing and testing various anti-
acanthamoebic drugs, recurrent infections, inadequate treatment outcomes, health …

[PDF][PDF] Acanthamoeba

NA Khan - Biology and pathogenesis, 2009 - caister.com
1. A host for viruses 2. A host for yeast 3. A host for protists 4. Acanthamoeba and bacteria
interactions 5. Is Acanthamoebaan evolutionary ancestor of macrophages? 6 …

Arctic marine fungi: biomass, functional genes, and putative ecological roles

BT Hassett, EJ Borrego, TR Vonnahme… - The ISME …, 2019 - academic.oup.com
Recent molecular evidence suggests a global distribution of marine fungi; however, the
ecological relevance and corresponding biological contributions of fungi to marine …

[HTML][HTML] Pharmacogenetics: an important part of drug development with a focus on its application

JT Oates, D Lopez - International journal of biomedical …, 2018 - ncbi.nlm.nih.gov
Since the human genome project in 2003, the view of personalized medicine to improve
diagnosis and cure diseases at the molecular level became more real. Sequencing the …

Nanoparticles based therapeutic efficacy against Acanthamoeba: Updates and future prospect

G Sharma, SK Kalra, N Tejan, U Ghoshal - Experimental Parasitology, 2020 - Elsevier
Acanthamoeba sp. is a free living amoeba that causes severe, painful and fatal infections,
viz. Acanthamoeba keratitis and granulomatous amoebic encephalitis among humans …

Statins and voriconazole induce programmed cell death in Acanthamoeba castellanii

CM Martín-Navarro, A López-Arencibia… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Members of the genus Acanthamoeba are facultative pathogens of humans, causing a sight-
threatening keratitis and a life-threatening encephalitis. In order to treat those infections …

[HTML][HTML] Pitavastatin loaded nanoparticles: a suitable ophthalmic treatment for Acanthamoeba Keratitis inducing cell death and autophagy in Acanthamoeba …

I Sifaoui, P Díaz-Rodríguez… - European Journal of …, 2022 - Elsevier
Statins are effective sterol lowering agents with high amoebicidal activity. Nevertheless, due
to their poor aqueous solubility, they remain underused especially in eye drop formulation …

Box Behnken design of siRNA-loaded liposomes for the treatment of a murine model of ocular keratitis caused by Acanthamoeba

GK Zorzi, RS Schuh, VJ Maschio, NT Brazil… - Colloids and Surfaces B …, 2019 - Elsevier
Acanthamoeba keratitis is an ophthalmic disease with no specific treatment that specially
affects contact lens users. The silencing of serine phosphatase (SP) and glycogen …

In Vitro Activity of Statins against Naegleria fowleri

A Rizo-Liendo, I Sifaoui, M Reyes-Batlle, O Chiboub… - Pathogens, 2019 - mdpi.com
Naegleria fowleri causes a deadly disease called primary amoebic meningoencephalitis
(PAM). Even though PAM is still considered a rare disease, the number of reported cases …