Inflammation in osteoarthritis: the latest progress and ongoing challenges

AJ Knights, SJ Redding, T Maerz - Current opinion in …, 2023 - journals.lww.com
Osteoarthritis is a debilitating chronic disease that manifests with widely varying
symptomatology. Inflammation is now appreciated as a key pathophysiological process in …

[HTML][HTML] Osteoarthritis year in review 2023: Biology

AJ Roelofs, C De Bari - Osteoarthritis and cartilage, 2024 - Elsevier
summary Great progress continues to be made in our understanding of the multiple facets of
osteoarthritis (OA) biology. Here, we review the major advances in this field and progress …

The role of genetics and epigenetic regulation in the pathogenesis of osteoarthritis

K Kiełbowski, M Herian, E Bakinowska… - International Journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is progressive disease characterised by cartilage degradation,
subchondral bone remodelling and inflammation of the synovium. The disease is associated …

Recent advances in small molecule inhibitors for the treatment of osteoarthritis

J Lin, S Jia, W Zhang, M Nian, P Liu, L Yang… - Journal of Clinical …, 2023 - mdpi.com
Osteoarthritis refers to a degenerative disease with joint pain as the main symptom, and it is
caused by various factors, including fibrosis, chapping, ulcers, and loss of articular cartilage …

[HTML][HTML] Epigenetic mechanisms of bone cancer pain

C Ni, L Chen, B Hua, Z Han, L Xu, Q Zhou, M Yao… - …, 2024 - Elsevier
The management and treatment of bone cancer pain (BCP) remain significant clinical
challenges, imposing substantial economic burdens on patients and society. Extensive …

Physical therapy as a promising treatment for osteoarthritis: A narrative review

W Wang, Y Niu, Q Jia - Frontiers in Physiology, 2022 - frontiersin.org
Osteoarthritis (OA) is the most prevalent joint disease and a leading cause of disability in
older adults. With an increasing population ageing and obesity, OA is becoming even more …

The degeneration-pain relationship in the temporomandibular joint: Current understandings and rodent models

MK Chung, S Wang, I Alshanqiti, J Hu… - Frontiers in Pain …, 2023 - frontiersin.org
Temporomandibular disorders (TMD) represent a group of musculoskeletal conditions
involving the temporomandibular joints (TMJ), the masticatory muscles and associated …

A brief review of current treatment options for osteoarthritis including disease-modifying osteoarthritis drugs (DMOADs) and novel therapeutics

P Jiang, K Hu, L Jin, Z Luo - Annals of Medicine and Surgery, 2024 - journals.lww.com
Osteoarthritis (OA) is a chronic disorder caused by degenerative changes in articular
cartilage, which are mainly manifests as degeneration of cartilage, subchondral bone …

IL-6 induces periostin production in human ACL remnants: a possible mechanism causing post-traumatic osteoarthritis

TH Tseng, CL Chen, CH Chang, JH Wang… - Journal of Orthopaedic …, 2023 - Springer
Abstract Objective Perostin (POSTN) and IL-6 consistently elevated after ACL injury, and
ACL has been proposed as the major source of POSTN. However, there is a lack of …

Hourglass, a rapid analysis framework for heterogeneous bioimaging data, identifies sex disparity in IL‐6/STAT3‐associated immune phenotypes in pancreatic cancer

K Aliar, HR Waterhouse, F Vyas, N Krebs… - The Journal of …, 2023 - Wiley Online Library
Integration and mining of bioimaging data remains a challenge and lags behind the rapidly
expanding digital pathology field. We introduce Hourglass, an open‐access analytical …