Although percutaneous renal mass biopsy with cross-sectional imaging guidance has long
been considered to be safe and accurate, there have been recent advances in imaging …

Renal cell carcinomas (RCC) are emerging as a complex set of diseases that are having a
major socioeconomic impact and showing a continued rise in incidence throughout the …

Clear cell renal cell carcinoma (ccRCC) is the predominant RCC subtype, but even within
this classification, the natural history is heterogeneous and difficult to predict. A sophisticated …

The product of the von Hippel-Lindau gene (VHL) acts as the substrate-recognition
component of an E3 ubiquitin ligase complex that ubiquitylates the catalytic α subunit of …

Background The diagnosis of benign renal oncocytomas (RO) and chromophobe renal cell
carcinomas (RCC) based on their morphology remains uncertain in several cases. Methods …

Despite the moderate incidence of papillary renal cell carcinoma (PRCC), there is a
disproportionately limited understanding of its underlying genetic programs. There is no …

Conventional genetic theories have failed to explain why cancer (1) is not heritable and thus
extremely rare in newborns,(2) is caused by non-mutagenic carcinogens,(3) develops only …

Since cancers have individual clonal karyotypes, are immortal and evolve from normal cells
treated by carcinogens only after exceedingly long latencies of many months to decades …

The nature of tubulocystic carcinoma, a rare renal tumor composed of tubular and cystic
structures, is poorly understood. It has been suggested that it may represent a low-grade …

Renal cell carcinoma is the most common neoplasm of the kidney. It is a heterogeneous
disease, comprised of different histological variants with a distinct clinical course, genetics …