This review aims to provide a systemic analysis of the in vivo, as well as subcellular, fate of
polymeric micelles (PMs), starting from the entry of PMs into the body. Few PMs are able to …

Over the last three decades, polymeric micelles have emerged as a highly promising drug
delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules …

Poly (ethylene glycol)(PEG) is widely used as a gold standard in bioconjugation and
nanomedicine to prolong blood circulation time and improve drug efficacy. The conjugation …

The present review sets out to discuss recent developments of the effects and mechanisms
of carrier properties on their circulation time. For most drugs, sufficient in vivo circulation time …

Abstract Poly (ethylene glycol)(PEG) as gold standard has been extensively conjugated to
diagnostic and therapeutic agents or decorated on the surface of nanoplatforms, which is …

For systemically delivered nanoparticles to reach target tissues, they must first circulate long
enough to reach the target and extravasate there. A challenge is that the particles end up …

The administration of drugs, as a main challenge of pharmaceutical and medicinal
applications, has certainly benefited from the application of synthetic polymers. However …

Peptides have important biological functions. However, their susceptibility to proteolysis
limits their applications. We demonstrated here for the first time, that poly (2 …

Abstract Poly (2-oxazoline) s are emerging innovative biomaterials that show analogous and
even preferable properties compared to well-known counterparts, especially poly (ethylene …

Therapeutics are habitually characterized by short plasma half-lives and little affinity for
targeted cells. To overcome these challenges, nanoparticulate systems have entered into …