Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

Although hormonal regulation of ovarian follicle development has been extensively
investigated, most studies concentrate on the development of early antral follicles to the …

The preservation of genome integrity in the mammalian female germline from primordial
follicle arrest to activation of growth to oocyte maturation is fundamental to ensure …

BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

The ovary, the female gonad, serves as the source for the germ cells as well as the major
supplier of steroid sex hormones. During embryonic development, the primordial germ cells …

BACKGROUND The first small follicles to appear in the mammalian ovaries are primordial
follicles. The initial pool of primordial follicles serves as the source of developing follicles …

Background The majority of oocytes in the mammalian ovary are dormant oocytes that are
enclosed in primordial follicles by several somatic cells, which we refer to as primordial …

Data derived principally from peripheral tissues (fat, muscle and liver) show that insulin
signals via diverse interconnecting intracellular pathways and that some of the major …

To maintain the female reproductive lifespan, the majority of ovarian primordial follicles are
preserved in a quiescent state in order to provide ova for later reproductive life. However, the …

In a society where women often want successful careers and equal opportunities to men, the
early nature of ovarian aging often forces women to make difficult life choices between …