Pseudomonas aeruginosa populations undergo a characteristic evolutionary adaptation
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …

The airways of patients with cystic fibrosis (CF) are nearly always infected with many
different microorganisms. This environment offers warm, humid and nutrient-rich conditions …

The bacterial pathogen Pseudomonas aeruginosa activates expression of many virulence
genes in a cell density-dependent manner by using an intricate quorum-sensing (QS) …

Quorum sensing (QS) is a widespread process in bacteria that employs autoinducing
chemical signals to coordinate diverse, often cooperative activities such as …

Pseudomonas aeruginosa uses a hierarchical quorum sensing (QS) network consisting of
las, pqs and rhl regulatory elements to coordinate the expression of bacterial virulence …

Many bacteria use a cell-cell communication system called quorum sensing to coordinate
population density-dependent changes in behavior. Quorum sensing involves production of …

Chronic Pseudomonas aeruginosa infections cause significant morbidity in patients with
cystic fibrosis (CF). Over years to decades, P. aeruginosa adapts genetically as it …

SUMMARY A select group of microorganisms inhabit the airways of individuals with cystic
fibrosis. Once established within the pulmonary environment in these patients, many of …

Bacterial pathogens evolve during the infection of their human host 1, 2, 3, 4, 5, 6, 7, 8, but
separating adaptive and neutral mutations remains challenging 9, 10, 11. Here we identify …

Quorum sensing (QS) is cell communication that is widely used by bacterial pathogens to
coordinate the expression of several collective traits, including the production of multiple …