Abstract Overactive phosphoinositide 3-kinase (PI3K) in cancer and immune dysregulation
has spurred extensive efforts to develop therapeutic PI3K inhibitors. Although progress has …

Signalling lipids such as eicosanoids, phosphoinositides, sphingolipids and fatty acids
control important cellular processes, including cell proliferation, apoptosis, metabolism and …

Background Particulate matter (PM) is a high risk factor for various respiratory diseases and
triggers an inflammatory response in lung tissues. However, the molecular mechanism of the …

Summary Phosphoinositide-3 kinase (PI3K)-δ and PI3K-γ are preferentially expressed in
immune cells, and inhibitors targeting these isoforms are hypothesized to have anti …

Rationale: Patients with chronic obstructive pulmonary disease (COPD) show a poor
response to corticosteroids. This has been linked to a reduction of histone deacetylase-2 as …

In respiratory diseases, there is an increased expression of multiple inflammatory proteins in
the respiratory tract, including cytokines, chemokines, and adhesion molecules …

Dysregulated signal transduction in innate and adaptive immune cells is known to be
associated with the development of various autoimmune and inflammatory diseases …

The generation of high-affinity Abs is essential for immunity and requires collaboration
between B and T cells within germinal centers (GCs). By using novel mouse models with a …

Environmental ultrafine particulate matter (PM) is capable of inducing airway injury, while
the detailed molecular mechanisms remain largely unclear. Here, we demonstrate pivotal …

Abstract Background Asthma and other Th2 inflammatory conditions have been associated
with increased susceptibility to viral infections. The mechanisms by which Th2 cytokines can …