Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

Even though the importance of epigenetics was first recognized in light of its role in tissue
development, an increasing amount of evidence has shown that it also plays an important …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …

Given the tissue-specific nature of epigenetic processes, the assessment of disease-relevant
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …

DNA methylation is critical for the normal development and functioning of the human brain,
such as the proliferation and differentiation of neural stem cells, synaptic plasticity, neuronal …

Tissue differences are one of the largest contributors to variability in the human DNA
methylome. Despite the tissue-specific nature of DNA methylation, the inaccessibility of …

Background The capacity of technologies measuring DNA methylation (DNAm) is rapidly
evolving, as are the options for applicable bioinformatics methods. The most commonly used …

Immunosenescence contributes to a decreased capacity of the immune system to respond
effectively to infections or vaccines in the elderly. The full extent of the biological changes …

Background Prenatal alcohol exposure is the leading preventable cause of behavioral and
cognitive deficits, which may affect between 2 and 5% of children in North America. While …

Background DNA methylation is influenced by both environmental and genetic factors and is
increasingly thought to affect variation in complex traits and diseases. Yet, the extent of …