The coordination of local translation, membranous organelle trafficking, and synaptic plasticity in neurons
Neurons are highly complex polarized cells, displaying an extraordinary degree of spatial
compartmentalization. At presynaptic and postsynaptic sites, far from the cell body, local …
compartmentalization. At presynaptic and postsynaptic sites, far from the cell body, local …
Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders
Alternative polyadenylation (APA) plays an essential role in brain development; however,
current transcriptome-wide association studies (TWAS) largely overlook APA in nominating …
current transcriptome-wide association studies (TWAS) largely overlook APA in nominating …
[HTML][HTML] Understanding neurodevelopmental disorders: the promise of regulatory variation in the 3′ UTRome
Neurodevelopmental disorders have a strong genetic component, but despite widespread
efforts, the specific genetic factors underlying these disorders remain undefined for a large …
efforts, the specific genetic factors underlying these disorders remain undefined for a large …
Widespread translational remodeling during human neuronal differentiation
Faithful cellular differentiation requires temporally precise activation of gene expression
programs, which are coordinated at the transcriptional and translational levels. Neurons …
programs, which are coordinated at the transcriptional and translational levels. Neurons …
PacBio Iso-Seq improves the rainbow trout genome annotation and identifies alternative splicing associated with economically important phenotypes
Rainbow trout is an important model organism that has received concerted international
efforts to study the transcriptome. For this purpose, short-read sequencing has been …
efforts to study the transcriptome. For this purpose, short-read sequencing has been …
Comprehensive catalog of dendritically localized mRNA isoforms from sub-cellular sequencing of single mouse neurons
SA Middleton, J Eberwine, J Kim - BMC biology, 2019 - Springer
Background RNA localization involves cis-motifs that are recognized by RNA-binding
proteins (RBP), which then mediate localization to specific sub-cellular compartments. RNA …
proteins (RBP), which then mediate localization to specific sub-cellular compartments. RNA …
cTag-PAPERCLIP reveals alternative polyadenylation promotes cell-type specific protein diversity and shifts Araf isoforms with microglia activation
Alternative polyadenylation (APA) is increasingly recognized to regulate gene expression
across different cell types, but obtaining APA maps from individual cell types typically …
across different cell types, but obtaining APA maps from individual cell types typically …
[HTML][HTML] The TORC1-regulated CPA complex rewires an RNA processing network to drive autophagy and metabolic reprogramming
Nutrient deprivation induces autophagy through inhibiting TORC1 activity. We describe a
novel mechanism in Drosophila by which TORC1 regulates RNA processing of Atg …
novel mechanism in Drosophila by which TORC1 regulates RNA processing of Atg …
Overlapping activities of ELAV/Hu family RNA binding proteins specify the extended neuronal 3′ UTR landscape in Drosophila
The tissue-specific deployment of highly extended neural 3′ UTR isoforms, generated by
alternative polyadenylation (APA), is a broad and conserved feature of metazoan genomes …
alternative polyadenylation (APA), is a broad and conserved feature of metazoan genomes …
Transcriptomics-proteomics Integration reveals alternative polyadenylation driving inflammation-related protein translation in patients with diabetic nephropathy
T Zhao, D Zhan, S Qu, S Jiang, W Gan, W Qin… - Journal of Translational …, 2023 - Springer
Background Diabetic nephropathy (DN) is a complex disease involving the upregulation of
many inflammation-related proteins. Alternative polyadenylation (APA), a crucial post …
many inflammation-related proteins. Alternative polyadenylation (APA), a crucial post …