Basic mechanisms of hemolysis-associated thrombo-inflammation and immune dysregulation

JD Dimitrov, LT Roumenina, G Perrella… - … , and Vascular Biology, 2023 - Am Heart Assoc
Independent of etiology, hemolytic diseases are associated with thrombosis, inflammation
and immune dysregulation, all together contributing to organ damage and poor outcome …

[HTML][HTML] Novel aspects of sepsis pathophysiology: NETs, plasma glycoproteins, endotheliopathy and COVID-19

M Nishibori - Journal of Pharmacological Sciences, 2022 - Elsevier
In 2016, sepsis was newly defined as life-threatening organ dysfunction caused by a
dysregulated host response to infection. Sepsis remains one of the crucial medical problems …

Hemin treatment drives viral reactivation and plasma cell differentiation of EBV latently infected B cells

AM Burnet, T Brunetti, R Rochford - PLoS Pathogens, 2023 - journals.plos.org
Epstein-Barr virus (EBV) and Plasmodium falciparum have a well described role in the
development of endemic Burkitt lymphoma (BL), yet the mechanisms involved remain …

Neutrophils as drivers of vascular injury in sickle cell disease

LS Torres, A Hidalgo - Immunological reviews, 2023 - Wiley Online Library
While neutrophils are the main effectors of protective innate immune responses, they are
also key players in inflammatory pathologies. Sickle cell disease (SCD) is a genetic blood …

ESL Attenuates BLM-induced IPF in Mice: Dual Mediation of the TLR4/NF-κB and TGF-β1/PI3K/Akt/FOXO3a Pathways

C Jia, M Yang, G Xiao, Z Zeng, L Li, Y Li, J Jiang, A Xu… - Phytomedicine, 2024 - Elsevier
Backgrounds Idiopathic pulmonary fibrosis (IPF) is a persistent and advanced pulmonary
ailment. The roles of innate immunity and adaptive immunity are pivotal in the evolution of …

Neutrophils in sickle cell disease: Exploring their potential role as a therapeutic target

LA de Ligt, AE Gaartman, BJ Biemond… - American journal of …, 2024 - Wiley Online Library
Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by chronic
hemolytic anemia and recurrent microvascular occlusions, resulting in acute painful events …

IL-8 Induces Neutrophil Extracellular Trap Formation in Severe Thermal Injury

A Asiri, J Hazeldine, N Moiemen… - International Journal of …, 2024 - mdpi.com
Neutrophil extracellular traps (NETs) have a dual role in the innate immune response to
thermal injuries. NETs provide an early line of defence against infection. However …

Role of macrophages in sickle cell disease erythrophagocytosis and erythropoiesis

R Sesti-Costa, FF Costa, N Conran - International Journal of Molecular …, 2023 - mdpi.com
Sickle cell disease (SCD) is an inherited blood disorder caused by a β-globin gene point
mutation that results in the production of sickle hemoglobin that polymerizes upon …

[HTML][HTML] Ferroptosis as an emerging target in sickle cell disease

V Fortuna, J Lima, GF Oliveira, YS Oliveira… - Current Research in …, 2024 - Elsevier
Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood cell
sickling, resulting in severe anemia, painful episodes, extensive organ damage, and …

Modulation of the Functional State of Mouse Neutrophils by Selenium Nanoparticles In Vivo

VN Mal'tseva, SV Gudkov, EA Turovsky - International Journal of …, 2022 - mdpi.com
This study aimed to discover the immunomodulatory effect of selenium nanoparticles
(SeNPs) on the functional state of neutrophils in vivo. Intraperitoneal injections of SeNPs …