Microtubules (composed of α-and β-tubulin heterodimers) play a pivotal role in mitosis and
cell division, and are regarded as an excellent target for chemotherapeutic agents to treat …

Low-molecular-weight vascular-disrupting agents (VDAs) cause a pronounced shutdown in
blood flow to solid tumours, resulting in extensive tumour-cell necrosis, while they leave the …

6-Diazo-5-oxo-l-norleucine (DON) is a glutamine antagonist that suppresses cancer cell
metabolism but concurrently enhances the metabolic fitness of tumor CD8+ T cells. DON …

A growing solid tumor relies on a developing vasculature to meet its needs in terms of
oxygen, nutrients, depuration, etc. This implies that if the vascular bed that has developed …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

It is over 50 years since the discovery of microtubules, and they have become one of the
most important drug targets for anti-cancer therapies. Microtubules are predominantly …

Discovering of new anticancer agents with potential activity against tubulin polymerisation is
still a promising approach. Colchicine binding site inhibitors are the most relevant anti …

Thirty-five new colchicine binding site inhibitors have been designed and synthesized based
on the 1, 2, 4-triazin-3 (2 H)-one nucleus. Such molecules were synthesized through a …

A clear definition for vascular targeting agents (VTAs) and vascular disrupting agents (VDAs)
has separated the two as distinct methods of cancer treatment. VDAs differ from VTAs …

Tumor blood vessel formation is a key process for tumor expansion. Tumor vessels are
abnormal and differ from normal vessels in architecture and components. Besides oxygen …