[HTML][HTML] Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19

J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

Toll-like receptors in antiviral innate immunity

SN Lester, K Li - Journal of molecular biology, 2014 - Elsevier
Toll-like receptors (TLRs) are fundamental sensor molecules of the host innate immune
system, which detect conserved molecular signatures of a wide range of microbial …

[PDF][PDF] Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract

JC Smith, EL Sausville, V Girish, ML Yuan… - Developmental cell, 2020 - cell.com
The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show
that cigarette smoke causes a dose-dependent upregulation of angiotensin converting …

[HTML][HTML] Epigenetic regulator miRNA pattern differences among SARS-CoV, SARS-CoV-2, and SARS-CoV-2 world-wide isolates delineated the mystery behind the …

MAAK Khan, MRU Sany, MS Islam… - Frontiers in genetics, 2020 - frontiersin.org
A detailed understanding of the molecular mechanism of SARS-CoV-2 pathogenesis is still
elusive, and there is a need to address its deadly nature and to design effective …

Intercellular communication within the virus microenvironment affects the susceptibility of cells to secondary viral infections

B Song, X Sheng, JL Justice, KK Lum, PJ Metzger… - Science …, 2023 - science.org
Communication between infected cells and cells in the surrounding tissue is a determinant
of viral spread. However, it remains unclear how cells in close or distant proximity to an …

Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival

ML DeDiego, JL Nieto-Torres, JA Regla-Nava… - Journal of …, 2014 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of a
respiratory disease that has a 10% mortality rate. We previously showed that SARS-CoV …

The airway epithelium: soldier in the fight against respiratory viruses

M Vareille, E Kieninger, MR Edwards… - Clinical microbiology …, 2011 - Am Soc Microbiol
The airway epithelium acts as a frontline defense against respiratory viruses, not only as a
physical barrier and through the mucociliary apparatus but also through its immunological …

[HTML][HTML] A review of cytokine-based pathophysiology of Long COVID symptoms

RN Low, RJ Low, A Akrami - Frontiers in Medicine, 2023 - frontiersin.org
The Long COVID/Post Acute Sequelae of COVID-19 (PASC) group includes patients with
initial mild-to-moderate symptoms during the acute phase of the illness, in whom recovery is …

Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome

CK Wong, CWK Lam, AKL Wu, WK Ip… - Clinical & …, 2004 - academic.oup.com
Severe acute respiratory syndrome (SARS) is a recently emerged infectious disease caused
by a novel coronavirus, but its immunopathological mechanisms have not yet been fully …

Lessons learned and unlearned in periodontal microbiology

R Teles, F Teles, J Frias‐Lopez, B Paster… - Periodontology …, 2013 - Wiley Online Library
Periodontal diseases are initiated by bacterial species living in polymicrobial biofilms at or
below the gingival margin and progress largely as a result of the inflammation elicited by …