Aging and cancer are the most important issues to research. The population in the world is
growing older, and the incidence of cancer increases with age. There is no doubt about the …

Cells in tissues and organs are continuously subjected to oxidative stress and free radicals
on a daily basis. This free radical attack has exogenous or endogenous (intracellular) origin …

The free radical theory of aging hypothesizes that oxygen-derived free radicals are
responsible for the age-related damage at the cellular and tissue levels. In a normal …

Inflammation is an essential immune response characterized by pain, swelling, redness,
heat, and impaired function. A controlled acute inflammatory response is necessary to fight …

To propose a new pathogenesis called Radical Induction to explain the genesis and
progression of ulcerative colitis (UC). UC is an inflammatory bowel disease. Colonic …

The ability to conduct validated analyses of biomarkers is critically important in order to
establish the sensitivity and selectivity of the biomarker in identifying a particular disease …

There is growing concern that air pollution exposure increases the risk of lung cancer. The
mechanism of action is related to particle-induced oxidative stress and oxidation of DNA …

Many components of the cell, including lipids, proteins and both nuclear and mitochondrial
DNA, are vulnerable to deleterious modifications caused by reactive oxygen species. If not …

Background: Oxidative stress may play an important role in both initiation and progression of
breast cancer. We conducted the first systematic epidemiologic review to summarize the …

Reactive oxygen and nitrogen species (ROS and RNS) are known to contribute as
pathogenic factors to the development of chronic progressive diseases at various stages …