In a healthy body, reactive oxygen species (ROS) and antioxidants remain balanced. When
the balance is broken toward an overabundance of ROS, oxidative stress appears and may …

Telomeres play a central role in cell fate and aging by adjusting the cellular response to
stress and growth stimulation on the basis of previous cell divisions and DNA damage. At …

Telomere shortening to a critical length can trigger aging and shorter life spans in mice and
humans by a mechanism that involves induction of a persistent DNA damage response at …

Mammalian telomeres contain a duplex array of telomeric repeats bound to the telomeric
repeat–binding factors TRF1 and TRF2. Inhibition of TRF2 results in immediate deprotection …

Direct visualization of genomic loci in the 3D nucleus is important for understanding the
spatial organization of the genome and its association with gene expression. Various DNA …

To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA
component (mTR) was deleted from the mouse germline. mTR−/− mice lacked detectable …

The reprogramming of differentiated cells to pluripotent cells (induced pluripotent stem (iPS)
cells) is known to be an inefficient process. We recently reported that cells with short …

Telomere maintenance is thought to play a role in signaling cellular senescence; however, a
link with organismal aging processes has not been established. The telomerase null mouse …

Relative quiescence is a defining characteristic of hematopoietic stem cells, while their
progeny have dramatic proliferative ability and inexorably move toward terminal …

We have investigated the role of the enzyme telomerase in highly proliferative organs in
successive generations of mice lacking telomerase RNA. Late-generation animals exhibited …