Objective Colorectal cancer (CRC) is the third most common cancer worldwide. The
geographical and temporal burden of this cancer provides insights into risk factor …

Objective To summarize the associations between potential causal factors and colorectal
cancer (CRC) risk based on existing Mendelian randomization studies. Methods This …

Background: Sex hormones may influence the development of gastrointestinal cancer, but
evidence is inconsistent. Methods: We systematically searched MEDLINE and Embase …

The colon is the largest hormonally active tissue in the human body. It has been known for
over a hundred years that various hormones and bioactive peptides play important roles in …

Background Colorectal cancer (CRC) is a leading cause of cancer-related mortality,
highlighting an unmet clinical need for more effective therapies. This study aims to evaluate …

Background: Endogenous sex hormones may contribute to higher colorectal cancer
incidence rates in men compared with women, but despite an increased number of studies …

Sexual dimorphism has been observed in the incidence and prognosis of colorectal cancer
(CRC), with men generally exhibiting a slightly higher incidence than women. Research …

Abstract Background In China, the quantity of physical activity differs from that in Western
countries. Substantial uncertainty remains about the relevance of physical activity for cancer …

Purpose To assess whether androgens play a role in explaining the sex related differences
in the incidence of colorectal cancer (CRC). Methods A nationwide matched cohort study …

Background: Epidemiological studies observed gender differences in COVID-19 outcomes,
however, whether sex hormone plays a causal in COVID-19 risk remains unclear. This study …