Neurofibromatosis type 1 is a complex autosomal dominant disorder caused by germline
mutations in the NF1 tumour suppressor gene. Nearly all individuals with neurofibromatosis …

Neurofibromin is a large and multifunctional protein encoded by the tumor suppressor gene
NF1, mutations of which cause the tumor predisposition syndrome neurofibromatosis type 1 …

Neurofibromatosis 1 (NF1) is a common neurocutaneous condition with an autosomal
dominant pattern of inheritance. The complications are diverse and disease expression …

Hereditary factors account for a significant proportion of breast cancer risk. Approximately
20% of hereditary breast cancers are attributable to pathogenic variants in the highly …

Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder that affects growth properties
of neural-crest-derived cell populations. In addition, approximately one-half of NF1 patients …

DEFECTS in the NF1 gene have been implicated in the inherited disorder neurofibromatosis
type 1, which is characterized by several developmental abnormalities including an …

The neurofibromatoses are a group of three heterogeneous disorders that include
neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis. NF1 …

Von Recklinghausen neurofibromatosis, or type 1 neurofibromatosis (NF1), is a common
autosomal dominant disorder characterized by abnormalities in multiple tissues derived from …

Individuals with the neurofibromatosis 1 (NF1) inherited tumor syndrome develop low-grade
gliomas (astrocytomas) at an increased frequency, suggesting that the NF1 gene is a critical …

Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome
that affects children and adults. Individuals with NF1 are at high risk for central nervous …