Many meta-analysis, large cohort studies, and experimental studies suggest that chronic
alcohol consumption increases the risk of gastric and colon cancer. Ethanol is metabolized …

Alcohol use disorder (AUD) is a high-risk psychiatric disorder and a key cause of death and
disability in individuals. In the development of AUD, there is a connection known as the …

Alcohol use disorders are common both in the United States and globally, and are
associated with a variety of co-morbid, inflammation-linked diseases. The pathogenesis of …

Alcohol and several therapeutic drugs, including acetaminophen, are metabolized by
cytochrome P450 2E1 (CYP2E1) into toxic compounds. At low levels, these compounds are …

Cellular CYP2E1 is well-known to mediate alcohol-(ALC) and acetaminophen-(APAP)
induced toxicity in hepatic and extra-hepatic cells. Although exosomes have been gaining …

The cytochrome P450 (CYP) family of enzymes is known to metabolize the majority of
xenobiotics. Hepatocytes, powerhouses of CYP enzymes, are where most drugs are …

Cancer is a leading cause of mortality globally. Cytochrome P450 (CYP) enzymes play a
pivotal role in the biotransformation of both endogenous and exogenous compounds …

Antiretroviral drugs have made significant progress in treating HIV-1 and improving the
quality of HIV-1-infected individuals. However, due to their limited permeability into the brain …

The purpose of this review is to briefly summarize the roles of alcohol (ethanol) and related
compounds in promoting cancer and inflammatory injury in many tissues. Long-term chronic …

Introduction While considerable progress has been made in the fight against HIV/AIDS, to
date there has not been a cure, and millions of people around the world are currently living …