Neuroprotective impact of linagliptin against cadmium-induced cognitive impairment and neuropathological aberrations: targeting SIRT1/Nrf2 axis, apoptosis, and …

HH Arab, AH Eid, SE Alsufyani, AM Ashour… - Pharmaceuticals, 2023 - mdpi.com
Cadmium is an environmental contaminant associated with marked neurotoxicity and
cognitive impairment. Linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, has …

Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats

HH Arab, AH Eid, R Yahia, SE Alsufyani, AM Ashour… - Pharmaceuticals, 2023 - mdpi.com
Cadmium is an environmental toxicant that instigates cognitive deficits with excessive
glutamate excitatory neuroactivity in the brain. Topiramate, a glutamate receptor antagonist …

Thymol and p‐Cymene Protect the Liver by Mitigating Oxidative Stress, Suppressing TNF‐α/NF‐κ B, and Enhancing Nrf2/HO‐1 Expression in Immobilized Rats

Y Peirovy, M Asle‐Rousta - Chemical Biology & Drug Design, 2024 - Wiley Online Library
This study aimed to investigate the effects of the monoterpenes thymol and p‐cymene on the
liver of rats subjected to prolonged immobilization stress and to discover the possible …

Puerarin Ameliorates Ferroptosis in Neuronal Injury Through the PI3K/AKT Signaling Pathway

R Hu, ZT Peng, H Liu - Nutrition and Cancer, 2025 - Taylor & Francis
Ferroptosis plays an important role in the pathogenesis of neuronal damage, generally
mediated by iron and lipid peroxidation. In the present study, we measured the protective …