This paper is the thirty-eighth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2015 …

Opioid maintenance therapy is a well-established first-line treatment approach in opioid
dependence. Buprenorphine, a partial opioid agonist, has been found by numerous studies …

The endogenous opioid system is thought to play an important role in the regulation of
mood. Buprenorphine/samidorphan (BUP/SAM) combination is an investigational opioid …

An improved synthesis of a haptenic heroin surrogate 1 (6-AmHap) is reported. The
intermediate needed for the preparation of 1 was described in the route in the synthesis of 2 …

Importance Nonadherence to buprenorphine may increase patient risk of opioid overdose
and increase health care spending. Quantifying the impacts of nonadherence can help …

Opioid use disorder (OUD) is currently an epidemic in the United States (US) and ibogaine
is reported to have the ability to interrupt opioid addiction by simultaneously mitigating …

We are in the middle of an opioid epidemic with tens of thousands of lives lost every year. As
we combat this problem, it is critically important that we continually scrutinize our research …

Background Opioid dependence treatment, comprising opioid substitution treatment (OST)
and psychosocial intervention, is accepted to improve outcomes in opioid addiction for both …

Prescription opioid misuse is an ongoing and escalating epidemic. Although these
pharmacological agents are highly effective analgesics prescribed for different types of pain …

Background Opioid substitution treatment (OST) with methadone or buprenorphine is the
most effective means of treating opioid dependence. If these substances are used by people …